Neonatal mice

Kopen, G. C., Prockop, D. J. and Phinney, D. G. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl Acad. Sci. U.S.A. 96 10711-10716,1999. 

Ji, F., Kanbara, N., and Obata, K. (1999) GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase. Neurosci. Res. 33, 187-194. 

Eriksson P, Nordbrg A (1990) Effects of two pyrethroids, bioallethrin and deltamethrin, on subpopulations of muscarinic and nicotinic receptors in the neonatal mouse brain. Toxicol Appl Pharmacol 102 456-463... 

Bern, H.A., Jones, L.A., and Mills, K.T. (1976). Use of the neonatal mouse in studying long-term effects of early exposure to hormones and other agents, J. Tbxicol. Environ. Health Supp. 1,103. 

Barker, J. Lewis, R.A. Deoxyguanosine kinase of neonatal mouse skin tissue. Biochira. Biophys. Acta, 658, 111-123 (1981)... 

Neonatal mouse pups, obtained within less than 16 h after birth, are injected in one eye with the therapeutic viral vector. The contralateral eye serves as a control and may remain uninjected, be mock-injected with carrier solution, or be injected with a non-therapeutic vector as the experiment indicates. Having determined that mock-injection or non-therapeutic injection did not impact the experimental model, our subsequent control eyes were uninjected. 

Studies have demonstrated that AAV serotypes 1 and 2 are able to efficiently transduce the murine heart for up to 10 months following GFP transgene delivery (Du et al., 2004). Recently, we have found that intravenous delivery to the neonatal mouse of the newly characterized AAV serotype 9 results in /i-galactosidase expression levels that are up to 50-fold higher in cardiac tissue than those obtained using AAV1 (Fig. 9.1) (Pacak, submitted 2004). The... 

Flammang TJ, Von Tungeln LS, Kadlubar FF, Fu PP. Neonatal mouse assay for tumorigenicity alternative to the chronic rodent bioassay. Regul Toxicol Pharmcol 1997 26 230 10. 

Furstenberger G, Schweizer J, Marks F. Development of phorbol ester responsiveness in neonatal mouse epidermis correlation between hyperplastic response and sensitivity to first-stage tumor promotion. Carcinogenesis 1985 6 289-94. 

McClain RM, Keller D, Casciano D,Fu P, MacDonald J, Popp J, Sagartz J. Neonatal mouse model review of methods and results. Toxicol Pathol 2001 29(Suppl) 128-37. 

COC (2002) Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC). COC statement on ILSI/HESI research programme on alternative cancer models. COC/02/S3, April 2002 Flammang TJ, Von Tungeln LS, Kadlubar FF, Fu PP (1997) Neonatal mouse assay for tumorigenicity. Alternative to the Chronic rodent bioassay. Reg Toxicol Pharmacol 26 230-240... 

Another and more convincing explanation for this discrepancy of previous and recent studies related to the inactivation of Cryptosporidium refers to the methods of viability testing. So, it seems that in vitro viability assays (chemical excystation and vital stains) that have been used previously may have significantly underestimated the inactivation efficacy of UV-C irradiation of the parasites compared with in vivo infectivity assays applied in recent studies using neonatal mouse models (Craik et al, 2001). This was also demonstrated by UV inactivation of Giardia muris cysts using MP Hg lamps (Craik et al., 2000). 

Hulsmann, S., Oku, Y., Zhang, W., Richter, D.W. (2000). Metabolic coupling between glia and neurons is necessary for maintaining respiratory activity in transverse medullary slices of neonatal mouse. Eur. J. Neurosci. 12 856-62. 

Gangarosa, L. R, Park, N. H., and Hill, J. M. lontophoretic assistance of 5-iodo-2 -deoxyuridine penetration into neonatal mouse skin and effects on DNA synthesis (39689). Proc. Soc. Exp. Biol. Med. 154 439, 1977. 

Four y-pyrones oxopodopyrone 9 (39), oxopodopyrone-8-methyl-9 (40), oxopodopyrone 10 (41), oxopodopyrone-8-methyl-lO (42), were isolated from the methanol extract of leaves of Gonsystylus keithii (Thymeliaceae). These compounds markedly inhibited the bovine parathjo oid hormone (PTH)-induced Ca release from neonatal mouse calvaria in vitro. The inhibitory activities of 39 to 42 were tested at the concentration of O.Olpg/ml, 0.1 lg/ml, l.Ojxg/ml and lO.Opg/ml each, the inhibitory activities of these compounds were assumed to be the same and were found to be more potent than those of calcitonins, etidronate and ipriflavone [37]. 

Balasingham, V., Tejeda-Berges, T., Wright, E., Bouckova, R., and Yong, V. W., Reactive gliosis in the neonatal mouse brain and its modulation by cytokines, J. Neurosci., 14, 846, 1994. 

He LM et al (2010) Synergistic effects of electrospun PLLA fiber dimension and pattern on neonatal mouse cerebellum C17.2 stem cells. Acta Biomater 6(8) 2960-2969... 

Broekman ML, Comer LA, Hyman BT, Sena-Esteves M. Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain. Neuroscience 2006 138 501-510. 

Eriksson P, Fredriksson A. 1996a. Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse. Environ Toxicol Pharmacol 1(3) 155-165. 

Neonatal mouse Cyclosporin Multiorgan-type inflammation... 

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