Absorption nasal

S Hirai, T Yashiki, H Mima. (1981). Mechanisms for the enhancement of the nasal absorption of insulin by surfactants. Int J Pharm 9 173-184. [Pg.385]

JP Longenecker, AC Moses, JS Flier, RD Silver, MC Carey, EJ Dubovi. (1987). Effects of sodium taurodihydrofusidate on nasal absorption of insulin in sheep. J Pharm Sci 76 351-355. [Pg.385]

Class D substances and with a 10 h half-time for Class W and Class Y substances. Absorption of material directly into blood is predicted to occur with a 15 min half-time for all compounds. Direct absorption is predicted for 0.5 of the Class D material, for 0.1 of the Class W material, and for 0.01 of the Class Y material. Cuddihy and Ozog (1973) studied direct absorption of 144CeCl3 solutions deposited in the nasal region of Syrian hamsters. About 0.04 of the deposited radiocerium was absorbed through the nasal membranes into the blood. This is about one-half of that predicted by the Task Group Model for nasal absorption of Class W compounds in humans. [Pg.26]

Cuddihy, R. G. and Ozog, J. A. (1973). Nasal absorption of CsCL, BaCl2, and CeCL, in Syrian hamsters, Health Phys. 25, 219. [Pg.82]

In addition to peptide-based studies, degradation and absorption kinetics of a homologous series of acyclovir ester prodrugs have been studied using the in situ perfusion model [25, 26], The studies showed that due to high esterase activity of the rat nasal mucosa (96% disappearance of hexanoate prodrug of acyclovir in 960 min), the rat in situ model is an acceptable model to screen the nasal absorption of prodrugs. [Pg.119]

Table 5.3 Factors affecting pharmacokinetics of nasal absorption [40],...

Wadell C, Bjork E, Camber O (2003) Permeability of porcine nasal mucosa correlated with human nasal absorption. Eur J Pharm Sci 18 47-53. [Pg.130]

Kato Y, Yagi N, Yamada S, Sato M, Kimura R (1992) Nasal absorption of digoxin in rats. J Pharmacobiodyn 15 1-6. [Pg.131]

Olivier JC, Djilani M, Fahmy S, Couet W (2001) In situ nasal absorption of midazolam in rats. Int J Pharm 213 187-192. [Pg.131]

Yang C, Mitra AK (2001) Nasal absorption of tyrosine-linked model compounds. J Pharm Sci 90 340-347. [Pg.131]

Huang CH, Kimura R, Nassar RB, Hussain A (1985) Mechanism of nasal absorption of drugs I Physicochemical parameters influencing the rate of in situ nasal absorption of drugs in rats. J Pharm Sci 74 608-611. [Pg.131]

Shao Z, Park GB, Krishnamoorthy R, Mitra AK (1994) The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2 /-esterprodrugs. Pharm Res 11 237-242. [Pg.131]

Shao Z, Mitra AK (1994) Bile salt-fatty acid mixed micelles as nasal absorption promoters. III. Effects on nasal transport and enzymatic degradation of acyclovir prodrugs. Pharm Res 11 243-250. [Pg.131]

Agu RU, Vu Dang H, Jorissen M, Willems T, Kinget R, Verbeke N (2002) Nasal absorption enhancement strategies for therapeutic peptides an in vitro study using cultured human nasal epithelium. Int J Pharm 237 179-191. [Pg.131]

Faraj JA, Hussain AA, Aramaki Y, Iseki K, Kagoshima M, Dittert LW (1990) Mechanism of nasal absorption of drugs. Ill Nasal absorption of leucine enkephalin. J Pharm Sci 79 698-702. [Pg.131]

Tengamnuay P, Sahamethapat A, Sailasuta A, Mitra AK (2000) Chitosans as nasal absorption enhancers of peptides comparison between free amine chitosans and soluble salts. Int J Pharm 197 53-67. [Pg.131]

Seki T, Kanbayashi H, Nagao T, Chono S, Tomita M, Hayashi M, Tabata Y, Morimoto K (2005) Effect of aminated gelatin on the nasal absorption of insulin in rats. Biol Pharm Bull 28 510-514. [Pg.131]

Wang J, Sakai S, Deguchi Y, Bi D, Tabata Y, Morimoto K (2002) Aminated gelatin as a nasal absorption enhancer for peptide drugs evaluation of absorption enhancing effect and nasal mucosa perturbation in rats. J Pharm Pharmacol 54 181— 188. [Pg.132]

Hosoya K, Kubo H, Natsume H, Sugibayashi K, Morimoto Y (1994) Evaluation of enhancers to increase nasal absorption using Ussing chamber technique. Biol Pharm Bull 17 316-322. [Pg.133]

Keywords Nasal absorption Air-interfaced culture Absorption enhancer Liquid-covered culture Mucociliary clearance Nasal epithelial cell mono-layer Paracellular absorption Tight junction Transcelluar absorption Drug transport... [Pg.216]

A. Hussain, S. Hirai, and R. Bawarshi. Nasal absorption of natural contraceptive steroids in rats-progesterone absorption. J Pharm Sci 70 466 167 (1981). [Pg.230]

Z. Shao, R. Krishnamoorthy, and A. K. Mitra. Cyclodextrins as nasal absorption promoters of insulin Mechanistic evaluations. Pharm Res 9 1157-1163 (1992). [Pg.230]

R. Kimura, M. Miwa, Y. Kato, S. Yamada, and M. Sato. Nasal absorption of tetraethylammonium in rats. Arch Int Pharmacodyn Ther 302 7-17 (1989). [Pg.231]

C. Tas, C. K. Ozkan, A. Savaser, Y. Ozkan, U. Tasdemir, and H. Altunav. Nasal absorption of metoclopramide from different Carbopol 981 based formulations In vitro, ex vivo and in vivo evaluation. Eur J Pharm Biopharm 64 246-254... [Pg.232]

Oechslein et al. [50] studied various powder formulations of mucoadhesive polymers for their efficacy to increase the nasal absorption of octreotide in rats. Although... [Pg.179]

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