Diethyl stilbestrol

STILBENYL-N,N-DIMETHYLAMINE see DUB800 STILBESTROL see DKA600 STILBESTROL DIETHYL DIPROPIONATE see DKBOOO... 

Diethyl stilbestrol Female genital tract - carcinoma (transplacental)... 

Roy, D, Floyd, R.A. and Liehr, J.G. (1991). Elevated 8-hydroxy-deoxy anosine levels in DNA of diethylstilbcstrol-treated Syrian hamsters covalent DNA damage by free radicals generated by redox cycling of diethyl-stilbestrol. Cancer Res. 51, 3882-3885. 

Estradiol (E2), ethynyl estradiol (EE) and synthetic estrogens such as diethyl stilbestrol (DES) were from the Sigma Chemical Company, Poole, Dorset, UK. Stocks were prepared in ethanol at 1 mM concentration and stored in glass vials at — 20°C. 

In addition to estrogen agonists based on steroid structures, a variety of nonsteroidal estrogens have also been synthesized and used clinically dienestrol (5.30), diethyl-stilbestrol (5.31), benzestrol (5.32), hexestrol (5.33), methestrol (5.34), methallenestril (5.35), and chlorotrianisene (5.36). 

Senekjian EK, Potkul RK, Frey K, Herbst AL. Infertility among daughters either exposed or not exposed to diethyl-stilbestrol. Am J Obstet Gynecol 1988 158(3 Pt l) 493-8. 

Barrett, J.C., A. Wong, and J.A. McLachlan. Diethyl-stilbestrol induces neoplastic transformation without measurable gene mutation at two loci. 

Henderson BE, Benton B, Cosgrove M, Baptista J, Aldrich J, Townsend D, Hart W, Mack TM (1976) Urogenital tract abnormalities in sons of women treated with diethyl-stilbestrol. Pediatrics, 58 505-507. 

Thermal decomposition of tetramethylammonium or trimethylanilinium salts was described for phenytoin methylation prior to its GC analysis in plasma [556] and diethyl-stilbestrol in biological fluids [557], Usually a liquid or homogenized sample is extracted into toluene, the respective tetrasubstituted ammonium hydroxide is added and the liquid phase is injected at 260—290°C. 

Newbold, R.R., Padilla-Banks, E., Jefferson, W.N. (2006). Adverse effects of the model environmental estrogen diethyl-stilbestrol are transmitted to subsequent generations. Endocrinology 147(6) (Suppl.) SI 1-17. 

While the Delaney Clause prevented the use of possibly dangerous chemicals such as diethyl-stilbestrol (DES), some prospectively useful substances were banned because improved analytical testing procedures... 

Trade names Diethyl Stilbestrol Diethylstilbestrol Distilbene Honvol Stilboestrol Stilphostrol... 

---