Medical Research Laboratories

Air Force. 1990. Development and validation of methods for applying pharmacokinetic data in risk assessment Volume n. Trichloroethylene. Wright-Patterson Air Force Base, OH U.S. Air Force, Air Force Systems Command, Harry G. Armstrong Medical Research Laboratory, Human Systems Division. NTIS No. AD-A237 366. 

Kinkead ER, Bashe WJ. 1987. Evaluation of the inhalation and skin absorption kinetics of a cyclotriphosphazene based hydraulic fluid. Report to Toxic Hazards Division of Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, OH. LR-86-03. February 1987. 

Kinkead ER, Culpepper BT, Henry SS. 1989c. Determination of the toxicity of cyclotriphosphazene hydraulic fluid by 21-day repeated dermal exposure. Harry G. Armstrong Aerospace Medical Research Laboratory Technical Report AAMRL-TR-89-022, 214-223... 

Kinkead ER, Wolfe RE, Bunger SK, et al. 1991. Evaluation of the toxic effects of a 90-day continuous exposure of rats to water-in-oil hydraulic fluid emulstions. Harry G. Armstrong Aerospace Medical Research Laboratory Technical Report AL-Tr-1991-015 NMRI-91-90. 

MacEwen JD, Vemot EH. 1983. Toxic Hazards Research Unit Annual Technical Report 1983. Air Force Aerospace Medical Research Laboratory. AFAMRL-TR-83-64. NTIS AD-136170. 

Levin, B.C. Paabo, M. Gunman, J.L. Harris, S.E. Braun, E. "Toxicological Interactions Between Carbon Monoxide and Carbon Dioxide," Proceedings of 16th Conference of Toxicology, Air Force Aerospace Medical Research Laboratory, Dayton, OH, October 1986 Toxicology 1987, 47, 135-164. 

Keller, W.C., C.T.Olson, and K.C.Back. 1984. Teratogenic assessment of three methylated hydrazine derivatives in the rat. J. Toxicol. Environ. Health 13 125-131. Kinkead, E.R., C.C.Haun, E.H.Vemot, and J.D.MacEwen. 1985. A chronic inhalation toxicity study on monomethylhydrazine. AFAMRL-TR-85-025. Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH. 

Environmental Toxicology. AMRL-TR-70-102. Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH. 

Pinkerton, M.K., E.A.Hagan, and K.C.Back. 1967. Distribution and excretion of 14C-monomethylhydrazine. AMRL-TR-67-175. Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH. 

Inhalation studies at the U.S. Air Force Aerospace Medical Research Laboratory showed an increased tumor response (hemangiosarcomas and Kupffer cell sarcomas) in mice exposed at 5 ppm, 6 h/d, 5 d/w for 6 mon (MacEwen and Vernot 1977, and Flaun 1977, reviewed in Trochimowicz 1994). Rats similarly exposed at 5 ppm exhibited increased incidences of squamous cell carcinomas of the lung and hepatocellular carcinomas. Hamsters subjected to a similar experimental protocol failed to show an increased incidence of tumors (MacEwen and Vernot 1975). It must be noted that the 1,1-dimethylhydrazine used in these studies contained 0.12% dimethylnitrosamine, which could be a significant confounder. 

Bungay PM, Dedrick RL, Matthews HB. 1982. Physiological modeling of enteric transport. Air Force Aerospace Medical Research Laboratory, Proceedings of the 12th Conference on Environmental Toxicology, 1981, 287-298. 

The Medical Research Laboratories (Building 355) were located about a mile south of our Grant Court apartment, and the larger Chemical Research and Development Laboratories (Building 320) were a mile and a half further down the same road. 

In 1961, the Kennedy administration gave a generous financial boost to medical research, further increasing the number of professionals. In terms of formal education, the staffing of the Edgewood Medical Research Laboratory was certainly far from shabby. I felt privileged to become part of its research team. 

Van M. Sim, M.D. (1922-1990) Trained as an internist, he was Chief of Clinical Research from 195S1961 and Chief Scientist of the Medical Research Laboratories thereafter. 

Volunteers on steps of the Medical Research Laboratory bu ilding, dressed in their best at the end of their two month assignment. 

This Decoration for Exceptional Civilian Service is awarded to Dr. Frederick R. Sidell of the Clinical Investigation Branch, Clinical Research Department, Medical Research Laboratory, Research Laboratories, Edgewood Arsenal, Maryland, for exemplary performance of duty during the period from August 1966 to February 1969. 

Thanks largely to his own prodigious output, his department published more scientific reports during the last two years than any within the Medical Research Laboratory. In both age and experience, he was unusually young to be given administrative and technical supervisory responsibility of the... 

LTC, Medical Corps, USA Chief, Clinical Research Dept Medical Research Laboratory Edgewood Arsenal, Maryland... 

In 1975, after reviewing all available documents, the Army IG (Inspector General) team had found nothing to indicate that anyone above the level of the President of the Intelligence Board or the Director of the Medical Research Laboratories at Edgewood had ever approved this proposal. Indeed, when interviewed in 1974, the former Commander of the Intelligence Center testified that he was completely unaware of the plan beforehand. The Intelligence Project Officer and the responsible physician at the Medical Research Laboratories (presumably Dr. Sim) evidently assumed the project had all the authorization it... 

While I was at Edgewood, I was imaware that anyone in the Medical Research Laboratories was involved in such collaboration. Information that came to light in the mid-1970s, however, leaves little doubt that at least two individuals at Edgewood did, in a sense, lead a compartmentalized double life, and participated in some highly secret CIA projects, both in the U.S. and overseas. 

Personal Letter from Army Private to the Commander of the Medical Research Laboratory, dated 5 December 1970, requesting details of the type of psychochemical drug, dose and possible effects on his future offspring. 

Figure 113 - Organizational chart for the Medical Research Laboratory (1969)...

Medical Research Laboratory, Edgewood Arsenal, MD, Unpublished manuscript, 1963... 

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