Syrian golden hamsters

Hamsters (Syrian Golden) Gavage in corn oil 125 ul/ kg for 7 weeks, then 62.5 ul/kg for 23 weeks Carcinoma of 1iver. Della Porta et al. (1961)... [Pg.224]

NDMMOR Syrian golden hamster 100 N.R. N.R. N-nitroso(2-hydroxypropyl-2-oxopropyl)amine (2, 24) N-nitroso-bis(2-hydroxy-propyl )amine (2, 24) 68... [Pg.55]

NPYR Syrian golden hamster Liver microsomes enhanced a-hydroxylation and mutagenicity in ethanol-consuming hamsters 10... [Pg.56]

These studies on NPYR are typical of the state of the art in cyclic nitrosamine metabolism ai d activation. The major metabolic pathways have been rather well characterized, but data on the relationship of these pathways to carcinogenesis are limited. This is especially true of the organospecific effects of NPYR and the other cyclic nitrosamines. For example, the main target organs for NPYR in the Syrian golden hamster are the trachea and nasal cavity rather than the liver. This is in spite... [Pg.61]

NPIP induces esophageal and nasal cavity tumors in the rat, forestomach, liver and lung tumors in the mouse, and tracheal tumors in the Syrian golden hamster (43, 44, 45). Its potent carcinogenicity is indicated by the fact that a single dose of only 22 mg/kg was sufficient to induce tumors in 20% of Syrian golden hamsters (45). The environmental occurrence of NPIP appears to be less frequent than that of NPYR, but it has been detected in food (J, 44). [Pg.66]

NHEX is a potent carcinogen which induces tumors of the liver and esophagus in rats, and tumors of the trachea in Syrian golden hamsters (50, 51). It has not been detected in the environment. ... [Pg.67]

NMOR is a potent hepatocarcinogen in the rat and induces tracheal and nasal cavity tumors in the Syrian golden hamster (43, 44, 45). It is formed readily from nitrite and morpholine in vitro and administration of these precursors to rodents causes tumors indicative of NMOR formation in vivo (44, 55, 56), NMOR has been detected in crankcase emissions of diesel engines and in factories engaged in rubber and tire manufacturing (57, 58). [Pg.68]

This then confiras the fact that NDELA penetrates the skin to act as an organ specific carcinogen as was also evident from the studies by Lijinsky jd on rats (25), from the reports by Edwards a on cosmetics in man (18) and from studies with Syrian golden hamsters in our laboratory (24). [Pg.258]

Genotoxic Effects. The Ames test with Salmonella typhimurium with and without s9 liver fractions from male Syrian golden hamsters or Sprague-Dawley rats indicates that hydrogen sulfide is not a mutagen (EPA 1984). A summary of genotoxicity studies is presented in Table 2-3. [Pg.108]

Parent RA, Casto BC. 1979. Effect of acrylonitrile on primary Syrian golden hamster embryo cells in culture Transformation and DNA fragmentation. J Natl Cancer Inst 62 1025-1029. [Pg.116]

Blair, P.C., M.B.Thompson, R.E.Morrissey, M.P.Moorman, R.A.Sloane, and B.A. Fowler. 1990a. Comparative toxicity of arsine gas in B6C3F1 mice, Fischer 344 rats, and Syrian golden hamsters system organ studies and comparison of clinical indices of exposure. Fundam. Appl. Toxicol. 14 776-787. [Pg.115]

Palmer, M. S., D. H. Swanson, and D. L. Coffin. Effect of ozone on benzpyrene hydroxylase activity in the Syrian golden hamster. Cancer Res. 31 730-733, 1971. [Pg.384]

Kruysse A, Eeron VJ, Til EIP Repeated exposure to acetaldehyde vapor. Studies in Syrian golden hamsters. Arch Environ Health 30 449-152, 1975... [Pg.14]

Willhite CC Developmental toxicology of acetonitrile in the Syrian golden hamster. Teratology 27 313-32 5, 1983... [Pg.20]

Rutkowski JV, Fermn VH Comparison of the teratogenic effects of isomeric forms of aminophenol in the Syrian Golden Hamster. Toxicol Appl Tharrmcol 63 264, 1982... [Pg.42]

The hepatocarcinogenicity of dieldrin in mice has been confirmed in several experiments, and in some cases, the liver cell tumors metastasized. No excess of tumors has been observed in a number of bioassays in rats and one bioassay in Syrian golden hamsters. ... [Pg.243]

Sellakumar AR, Laskin S, Kuschner M, et al Inhalation carcinogenesis by dimethylcar-bamoyl chloride in Syrian golden hamsters. J Environ Pathol Toxicol 4 107-115, 1980... [Pg.265]

Tomatis L, Magee PN, Shubik P Induction of liver tumors in the Syrian golden hamster by feeding dimethylnitrosamine. J Natl OtwcerZ/wt 33 341-345, 1964... [Pg.533]

Pour P, Kruger FW, Cardesa A, et al Carcinogenic effect of di- -propylnitrosamine in Syrian golden hamsters. J Natl Cancer Inst 51(3) 1019-1027, 1973... [Pg.536]

Freundenthal RI, Thake DC, Baron RL Project Summary-Carcinogenic Potential of Rotenone Subchronic Oral and Peritoneal Administration to Rats and Chronic Dietary Administration to Syrian Golden Hamsters, Health Effect Research Laboratory Report EPA-66/Si-81-037. Research Triangle Park, NC, US Environmental Protection Agency, 1981... [Pg.621]

Hirose M, Inoue T, Asamoto M, et al. 1986. Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labeling indices of the glandular stomach and urinary bladder epithelium of Syrian golden hamsters. Carcinogenesis 7(8)... [Pg.152]

Wehner AP, Stuart BO, Sanders CL. 1979. Inhalation studies with Syrian golden hamsters. Prog Exp Tumor Res 24 177-198. [Pg.256]

Ivankovic S (1979) Teratogenic and carcinogenic effects of some chemicals dimng prenatal life in rats, Syrian golden hamsters, and minipigs. Natl Cancer Inst Monogr 51 103-115... [Pg.167]

Zheng, R. Hess, K. Ostergren, ]. Haworth and N. Knutson. Beta-glucan franctions from barley and oats are similarly antiatherogenic in hypercho-lesterolemic Syrian golden hamsters. J Nutr 2003 133(2) 468-475. [Pg.262]

Powdered hydroalcoholic extract of the leaf was administered to Syrian golden hamster (ChCM). The extract was added to the... [Pg.267]

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