Sodium methyl hydroxybenzoate

Synonyms E219 methyl 4-hydroxybenzoate sodium salt sodium methyl hydroxybenzoate soluble methyl hydroxybenzoate. 

Preservative 219 Sodium methyl p-hydroxybenzoate 10 35th Series 2001... 

Succinylcholine solutions contained 0.05% (w/v) methyl- -hydroxybenzoate as stabilizer. Phenytoin (sodium salt) and decanol were supplied by Sigma (St. Louis, MO) other materials were tricaprylylmethylammoniura chloride or Aliquat 336S (General Mills Chemicals, Inc., Kankakee, IL). Solutions of sodium phenytoin were prepared by serial dilution while keeping both pH and ionic strength at constant values, 10 and 0.1 mol/1, respectively. The selectivity coefficients were determined at pH 10.0 and 0.1 mol/1 ionic strength, both adjusted with borax-NaOH buffer solution of pH 10.0. 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

Synonyms. Sodium Methylparaben Soluble Methyl Hydroxybenzoate. Proprietary Name. Nipagin M Sodium C8H7Na03 = 174.1 CAS—5026-62-0... 

E215 Sodium ethyl p-hydroxybenzoate E216 Propyl p-hydroxybenzoate E217 Sodium propyl p-hydroxybenzoate E218 Methyl p-hydroxybenzoate E219 Sodium methyl p-hydroxybenzoate2... 

See Sodium dinaphthalene methane sulfonate Sodium N-methylglycinate Sodium N-methylglycine. See Sodium sarcosinate Sodium methyl 4-hydroxybenzoate Sodium methyl p-hydroxybenzoate. See Sodium methyl paraben... 

Synonyms 4-Hydroxybenzoic acid, methyl ester, sodium salt Methylparaben sodium Methylparaben sodium salt Sodium 4-(methoxycarbonyl) phenolate Sodium methyl 4-hydro xybenzoate Sodium methyl p-hydroxybenzoate Definition Sodium salt of methylparaben Empiricai CsHyNaOs Properties Wh. powd. freely sol. in water sparingly sol. in alcohol insol. in fixed oils m.w. 174.14 pH 9.5-10.5 (1 in 1000)... 

E219 Sodium methyl p-hydroxybenzoate E280 Propionic acid... 

Methyl /)-hydroxybenzoate does not appear to show changes in spectral characteristics in the presence of large amounts of methanol but differences are observed in aqueous solutions. In phosphate buffer at pH 7 5 methyl hydroxybenzoate shows maximum absorption at 257 m// and in 0-lN sodium hydroxide at 296 mfi. 

Boil about 01 g with 50 ml of N sodium hydroxide for thirty minutes under reflux. Cool, add 50 ml of 01N bromine and 10 ml of concentrated hydrochloric acid. Allow to stand for half an hour, shaking repeatedly during the first fifteen minutes, add 2 g of potassium iodide and titrate the liberated iodine with O IN sodium thiosulphate. 1 ml of 0 1 N bromine == 0 002536 g methyl hydroxybenzoate, CgHgOa 0 002902 g sodium salt of the methyl ester 0 003003 g propyl hydroxybenzoate, C10H12C3, and 0 003370 g sodium salt of the propyl ester. 

Condensation of aromatic methylesters such as methyl 4-methoxybenzoate 351 a or methyl 4-hydroxybenzoate 351b with excess sodium-HMDS 486 in a mixture of THF-l,3-dimethyl-imidazolin-2-one (DMEU) at 185 °C in a closed vessel affords 59 or 93% of 4-hydroxybenzonitrile 298 as well as 26% 352 with smooth cleavage of the aromatic methyl ether in 351a (Scheme 4.47). Methyl indole-3-carboxylate gives hkewise 3-cyanoindole in 81% yield [127] (cf. also ref [92] in section 4.3). 

C12 to C20, primarily Ci6 to ( is), used as surface lubricants in the manufacture of food-contact articles. The method, which uses ethyl palmitate (Eastman Chemicals No. 1575 Red Label) as an internal standard, has been validated at 200 ppm total FAME [185]. Other FAME standards (methyl palmitate, methyl stearate, methyl oleate, methyl linoleate and methyl linolenate) are available (Applied Science Laboratories) [116], Worked out examples of additive determinations are given in the Food Additives Analytical Manual [116], which also describes a great many of indirect food additives, such as BHA, BHT, TBHQ, l-chloro-2-propanol, DLTDP, fatty acid methyl esters, w-heptyl-p-hydroxybenzoate, propyl-gallate, sodium benzoate, sodium stearoyl-2-lactylate, sorbitol and phenolic antioxidants. EPA methods 606 and 8060 describe the CGC separation of phthalate esters (direct injection) (cf. Figure 4.2). 

There is a recent trend towards simultaneous CE separations of several classes of food additives. This has so far been applied to soft drinks and preserved fruits, but could also be used for other food products. An MEKC method was published (Lin et al., 2000) for simultaneous separation of intense sweeteners (dulcin, aspartame, saccharin and acesulfame K) and some preservatives (sorbic and benzoic acids, sodium dehydroacetate, methyl-, ethyl-, propyl- and isopropyl- p-hydroxybenzoates) in preserved fruits. Ion pair extraction and SPE cleanup were used prior to CE analysis. The average recovery of these various additives was 90% with good within-laboratory reproducibility of results. Another procedure was described by Frazier et al. (2000b) for separation of intense sweeteners, preservatives and colours as well as caffeine and caramel in soft drinks. Using the MEKC mode, separation was obtained in 15 min. The aqueous phase was 20 mM carbonate buffer at pH 9.5 and the micellar phase was 62 mM sodium dodecyl sulphate. A diode array detector was used for quantification in the range 190-600 nm, and limits of quantification of 0.01 mg/1 per analyte were reported. The authors observed that their procedure requires further validation for quantitative analysis. 

A paired-ion, reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of sweeteners (dulcin, saccharin-Na, and acesulfame-K), preservatives (sodium dehydroacetate, SA, salicyclic acid, BA, succinic acid, methyl-para-hydroxybenzoic acid, ethyl-para-hydroxybenzoic acid, n-propyl-para-hydroxybenzoic acid, n-butyl-para-hydroxybenzoic acid, and isobutyl-para-hydroxybenzoic acid), and antioxidants (3-tertiary-butyl-4-hydroxyanisole and tertiary-butyl-hydroquinone). A mobile phase of acetonitrile-50 ml aqueous tr-hydroxyisobutyric acid solution (pH 4.5) (2.2 3.4 or 2.4 3.6, v/v) containing 2.5 mM hexadecyltrimethylammonium bromide and a Clg column with a flow rate of 1.0 ml/min and detection at 233 nm were used. This method was found to be very reproducible detection limits ranged from 0.15 to 3.00 p,g. The retention factor (k) of each additive could be affected by the concentrations of hexadecyltrimethylammonium bromide and a-hydroxyisobu-tyric acid and the pH and ratio of mobile phase. The presence of additives in dried roast beef and sugared fruit was determined. The method is suitable for routine analysis of additives in food samples (81). 

Then, 1.3 ml of glycerine are mixed with 0.5 ml of a 25% solution of methyl p-hydroxybenzoate in ethanol, and 50 ml of distilled water are added. To the produced mixture are, after sterile filtration, added 10 ml of the stock solution 1, 2.5 ml of the stock solution 2 and 10 ml of the stock solution 3, after which 3.0 ml of sterile 0.1 N sodium hydroxide are added, and the mixture is filled up with sterile distilled water to a volume of 100 ml. The insulin will be precipitated amorphously by the admixture of the sodium hydroxide, and the produced suspension acquires the pH value of 7. It will contain approximately 1 gamma zinc per insulin unit. 

This group of chemicals, which are found naturally in many fruits, are used as preservatives, a function that they also perform within fruit. Benzoic acid itself may be used, or more commonly sodium benzoate (a salt) or ethyl or methyl para-hydroxybenzoate, also known as parabens. They have sometimes associated with adverse effects. Anaphylaxis-like reactions have been reported as well as urticaria. About 4 per cent of people who suffer from asthma may experience breathlessness and wheezing when exposed to benzoates. Parabens are often used as preservatives cosmetics. 

McDonald C, Lindstrom RE. The effect of urea on the solubility of methyl p-hydroxybenzoate in aqueous sodium chloride solution. / Pharm Pharmacol 1974 26 39 5. 

Phenol acids are phenols in which there is also a carboxylic acid group attached to the benzene ring. They include salicylic acid (ortho-hydroxybenzoic acid) and para-hydroxy-benzoic acid (Figure 25.8). Acetylsalicylic acid (aspirin) and sodium salicylate are derivatives of salicylic acid. Like phenol, they have antipyretic and analgesic properties. The methyl, ethyl and propyl esters of para-hydroxybenzoic acid (parabens) are used as preservatives in pharmaceuticals, cosmetics and foodstuffs. 

Benzyl Salicylate, 2-Hydroxybenzoic acid phenyl methyl ester salicylic acid benzyl ester. CKH mol wt 228.24. C 73.677°, H 5.307°, O 21.03%. Prepd from sodium alkylate and benzyl chloride Volwiler, Vliet, J. Am. Chem. See 43, 1672 (1921). 

Nitration of p-cymene by fuming nitric add leads to 2,4-dinitrotoluene.1184 Heating 1,6-dihydro-l-methyl-6-oxonicotinic acid with nitric acid (d 1.52) under reflux gives 1-methyl-3,5-dinitro-2(li/)-pyridone in good yield.1185 2,6-Dibromo-4-nitrosophenol is formed quantitatively from 3,5-dibromo-4-hydroxybenzoic acid and sodium nitrite in aqueous alcohol.166,1183 Nitrous acid replaces hydroxymethyl groups in phenols by nitro groups,1186 and diazonium salts replace them by diazo groups.1187... 

To a solution of NaOEt prepared from 0.11 g sodium (4.7 mmol) and 10 mL absolute ethanol, cooled in an ice bath, was added in rapid succession 0.88 g methyl 2-chloro-6-hydroxybenzoate (4.7 mmol) and a solution of 1.14 g A-4-methoxyphenylbenzimidyl chloride (4.7 mmol) in 30 mL dry ether. The reaction mixture was shaken vigorously, whereupon a precipitate of sodium chloride began to form. The mixture was allowed to stand at room temperature for 48 h, the solvent was evaporated, and the residue was diluted with water. The resulting oily solid was removed by extraction with ether, the ethereal solution was dried, and the ether was distilled. The crude imido ester was heated in a nitrogen atmosphere at 210-215 C for 70 min, then dissolved in 10.8 mL ethanol the alcoholic solution was diluted with 5.4 mL water and 5.4 mL of a 1 M ethanolic sodium ethoxide. The solution was refluxed for 1.5 h, the alcohol was evaporated on a steam bath, and the aqueous solution was acidified with dilute HCl. The dark oil that formed was separated by decantation, and the crude benzoate of the substituted anthranilic acid was dissolved in 22 mL ethanol. A solution of 7.2 g sodium hydroxide in 7.2 mL water was added, and the mixture was refluxed for 1 h. The alcohol was evaporated, and the solution was then acidified. The brown solid was extracted exhaustively with boiling water to remove the benzoic acid, and the remaining brown solid was recrystallized from aqueous ethanol. The yellow needle-like crystals of A-(4 -methoxyphenyl)-6-chloroanthranilic acid, in a total amount of 0.36 g, was obtained, in a yield of 27.7%, m.p., 139.5-140.5°C (dec). 

Hydroxybenzoic acid, methyl ester, potassium salt. See Potassium methylparaben 4-Hydroxybenzoic acid, methyl ester, sodium salt. See Sodium methylparaben 4-Hydroxybenzoic acid, 1-methylethyl ester. 

The 2-hydroxybenzo[h]thiophen system exists in the thiolactone form (387), but gives upon dimethyl sulphate methylation of its sodium salt... 

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