Methyl hydroxybenzoate sodium salt

Synonyms E219 methyl 4-hydroxybenzoate sodium salt sodium methyl hydroxybenzoate soluble methyl hydroxybenzoate. 

Hydroxybenzoic acid, methyl ester, potassium salt. See Potassium methylparaben 4-Hydroxybenzoic acid, methyl ester, sodium salt. See Sodium methylparaben 4-Hydroxybenzoic acid, 1-methylethyl ester. 

Synonyms 4-Hydroxybenzoic acid, methyl ester, sodium salt Methylparaben sodium Methylparaben sodium salt Sodium 4-(methoxycarbonyl) phenolate Sodium methyl 4-hydro xybenzoate Sodium methyl p-hydroxybenzoate Definition Sodium salt of methylparaben Empiricai CsHyNaOs Properties Wh. powd. freely sol. in water sparingly sol. in alcohol insol. in fixed oils m.w. 174.14 pH 9.5-10.5 (1 in 1000)... 

Succinylcholine solutions contained 0.05% (w/v) methyl- -hydroxybenzoate as stabilizer. Phenytoin (sodium salt) and decanol were supplied by Sigma (St. Louis, MO) other materials were tricaprylylmethylammoniura chloride or Aliquat 336S (General Mills Chemicals, Inc., Kankakee, IL). Solutions of sodium phenytoin were prepared by serial dilution while keeping both pH and ionic strength at constant values, 10 and 0.1 mol/1, respectively. The selectivity coefficients were determined at pH 10.0 and 0.1 mol/1 ionic strength, both adjusted with borax-NaOH buffer solution of pH 10.0. 

Prochlorperazine Edisylate Prochlorperazine edisylate is not compatible with sodium chloride solutions containing methyl hydroxybenzoate and propyl hydroxy-benzoate as preservatives, but is compatible with solutions containing benzyl alcohol. Prochlorperazine edisylate salts are incompatible with a number of drugs such as aminophylline, amphotericin, ampicillin sodium, some barbiturates, ben-zylpenicillin salts, calcium gluconate, cefmetazole sodium, cephalothin sodium, chloramphenicol sodium succinate, chlorothiazide sodium, chloramphenicol, morphine sulfate containing phenol, magnesium trisilicate mixture, sodium succinate, chlorothiazide sodium, dimenhydrinate, heparin sodium, hydrocortisone sodium succinate, midazolam hydrochloride, and some sulfonamides.166... 

The 2-hydroxybenzo[h]thiophen system exists in the thiolactone form (387), but gives upon dimethyl sulphate methylation of its sodium salt... 

Applications. In many countries the methyl, ethyl and n-propyl esters of p-hydroxybenzoic acid, as well as their sodium salts, are permitted for preservation of some foods. The maximum permissible quantity is around 0.1%. In the USA methyl- and propyl-paraben are considered GRAS. The maximum permissible quantity is 0.1%. Their main field of use is not food preservation but the preservation of pharmaceutical and cosmetic fat emulsions. The usage of the butyl ester is not allowed in food applications. 

Boil about 01 g with 50 ml of N sodium hydroxide for thirty minutes under reflux. Cool, add 50 ml of 01N bromine and 10 ml of concentrated hydrochloric acid. Allow to stand for half an hour, shaking repeatedly during the first fifteen minutes, add 2 g of potassium iodide and titrate the liberated iodine with O IN sodium thiosulphate. 1 ml of 0 1 N bromine == 0 002536 g methyl hydroxybenzoate, CgHgOa 0 002902 g sodium salt of the methyl ester 0 003003 g propyl hydroxybenzoate, C10H12C3, and 0 003370 g sodium salt of the propyl ester. 

This group of chemicals, which are found naturally in many fruits, are used as preservatives, a function that they also perform within fruit. Benzoic acid itself may be used, or more commonly sodium benzoate (a salt) or ethyl or methyl para-hydroxybenzoate, also known as parabens. They have sometimes associated with adverse effects. Anaphylaxis-like reactions have been reported as well as urticaria. About 4 per cent of people who suffer from asthma may experience breathlessness and wheezing when exposed to benzoates. Parabens are often used as preservatives cosmetics. 

Nitration of p-cymene by fuming nitric add leads to 2,4-dinitrotoluene.1184 Heating 1,6-dihydro-l-methyl-6-oxonicotinic acid with nitric acid (d 1.52) under reflux gives 1-methyl-3,5-dinitro-2(li/)-pyridone in good yield.1185 2,6-Dibromo-4-nitrosophenol is formed quantitatively from 3,5-dibromo-4-hydroxybenzoic acid and sodium nitrite in aqueous alcohol.166,1183 Nitrous acid replaces hydroxymethyl groups in phenols by nitro groups,1186 and diazonium salts replace them by diazo groups.1187... 

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