Ointment bases petrolatum

Ointments and Creams Ointments are applied to the skin for topical treatment or to be absorbed into the blood system for delivery to target areas. They are semisofid preparations obtained by mixing the API with selected ointment bases depending on intended use. These bases include petrolatum, paraffin, mineral oil, lanolin, and glycols. Preservatives are often added to ensure the ointments will maintain the recommended shelf life. 

Ointments are commonly used for topical application of drugs to the eye.These vehicles are primarily mixtures of white petrolatum and liquid mineral oil with or without a water-miscible agent, such as lanolin.The mineral oil is added to the petrolatum to allow the vehicle to melt at body temperature, and the lanolin is added to the nonemulsive ointment base to absorb water. This allows for water and water-soluble drugs to be retained in the delivery system. Commercial ophthalmic ointments are derivatives of a hydrocarbon mixture of 60% petrolatum USP and 40% mineral oil USP, forming a molecular complex that is semisolid but melts at body temperature. In general, ointments are well tolerated by the ocular tissues, and when antibiotics are incorporated they are usually more stable in ointment than in solution. 

Ointments are composed mostly of fluid hydrocarbons meshed in a mafrix of higher melting solid hydrocarbons. Common examples of ointment bases include mineral oil, petrolatum, and polyethylene glycol. Creams are semisolid emulsion systems with an opaque... 

Petrolatum is mainly used in topical pharmaceutical formulations as an emollient-ointment base it is poorly absorbed by the skin. Petrolatum is also used in creams and transdermal formulations and as an ingredient in lubricant formulations for medicated confectionery together with mineral oil. 

Viscosity (dynamic) the rheological properties of petrolatum are determined by the ratio of the unbranched chains to the branched chains and cyclic components of the mixture. Petrolatum contains relatively high amounts of branched and cyclic hydrocarbons, in contrast to paraffin, which accounts for its softer character and makes it an ideal ointment base. ... 

Petrolatum and lanolin alcohols is a soft solid used in topical pharmaceutical formulations and cosmetics as an ointment base with emollient properties. It is also used in the preparation of creams and lotions. Petrolatum and lanolin alcohols can be used to absorb wound exudates. See Table I. 

In its strictest definitive form, an ointment is classified as any semi-solid containing fatty material and intended for external application (U.S. Pharmocopeia, USP). In this discussion, ointments will be defined as semisolid anhydrous external preparations. In the nineteenth century, ointments were based on lard, a compounding material, the usefulness of which was severely limited by its tendency to turn rancid. Early in the twentieth century, lard was replaced by petrolatum (white or yellow soft paraffin or petroleum jelly). In present practice, nonmedicated ointments (ointment bases) are used alone, for emollient or lubricating purposes, or in combination with a drug for therapeutic purposes. 

The ointment contains fluocinonide 0.5 mg/g in a specially formulated ointment base consisting of glyceryl monostearate, white petrolatum, propylene carbonate, propylene glycol, and white wax. It provides the occlusive and emollient effects desirable in an ointment. In this formulation, the active ingredient is totally in solution. In another formulation, the ointment contains fluocinolone acetonide 0.25 mg/g in a white petroleum USP vehicle. 

Each gram of ointment 0.1% contains 1 mg mometasone furoate in an ointment base of hexylene glycol, phosphoric acid, propylene glycol stearate, white wax, white petrolatum, and purified water. 

Ointment Base. [Penreco] White petrolatum USP ointment baise for eye and sldn medications caariers for medical materials. 

Dark-brown, viscous, oily liq. Odor of burnt petroleum, A 0.970-0,980. Immiscible with water. Freely sol in ale, volatile and fixed oils. Marketed as a 17% ointment, which also contains 4% titanium dioxide in an ointment base consisting of beeswax cetyl alcohol, lanolin, and petrolatum,... 

Chem, Descrip. Wh. petrolatum LISP CAS 8027-32-5 EINECS/ELINCS 232-373-2 Uses Ointment base for ophthalmic and topical ointments carrier for medical materials absorption base in cosmetics food-contact applies. release agent, lubricant, sealant, polishing agent, protective coating, defoamer in foods... 

Avatar White Petrolatum Avatar Yeiiow Petrolatum Molder s Edge ME-301 NS Ointment Base No. 3 Ointment Base No. 4 Ointment Base No. 6 Penreco Amber Penreco Blond Penreco Cream Penreco Lily Penreco Regent Penreco Royal Penreco Snow Penreco Super Penreco Ultima Perfecta ... 

Uses white petrolatum is a purified mixture of semisolid hydrocarbons used as an ointment base in cosmetics leather grease and shoe polish component... 

Poloxamers have also been incorporated into white petrolatum USP ointment bases in the presence of dimethylsulphoxide to modify the absorption of drugs presented in the base [252]. Percutaneous absorption of salicylic acid was increased significantly by poloxamers 231 and 182 and absorption of sodium salicylate by poloxamer 182. 

Chem. Descrip. Petrolatum, decyl oleate, dicocoyl pentaerythrityl distearyl citrate, sorbitan sesquioleate, ceresin, mineral oil, beeswax, aluminum stearate Uses SE ointment base for mfg. of cosmetic and pharmaceutical preparations of the w/o type... 

Ophthalmic ointments usually contain petrolatum as the base. The petrolatum is sterilized by dry heat and combined with the sterile dmg powder under aseptic conditions. Ophthalmic suspensions contain very fine (- 10 ji) particle sized soHds suspended in an aqueous vehicle. The vehicle is adjusted to isotonicity and viscosity-increasing excipients, chelating agents, and surfactants also may be needed. The aqueous vehicle in these cases is generally autoclaved and mixed with sterile dmg powder asceptically (30). 

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