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Base ointment

When an ophthalmic ointment is manufactured, all raw material components must be rendered sterile before compounding unless the ointment contains an aqueous fraction that can be sterilized by heat, filtration, or ionizing radiation. The ointment base is sterilized by heat and appropriately filtered while molten to remove extraneous foreign particulate matter. It is then placed into a sterile steam-jacketed kettle to maintain the ointment in a molten state under aseptic conditions, and the previously sterilized active ingredients) and excipients are added aseptically. While still molten, the entire ointment may be passed through a previously sterilized colloid mill for adequate dispersion of the insoluble components. [Pg.452]

A device was designed for use in studying the release of corticosteroids suspended in an oleaginous ointment base [20], The apparatus consists of a Teflon dish which floats on the surface of the stirred receptor fluid. After the system has been brought to thermal equilibrium, a known amount of ointment is evenly spread on the bottom surface of the Teflon dish. At particular time intervals,... [Pg.111]

Method for oleaginous ointment bases (free boundary method) Mass transport from water-immiscible ointment bases 20... [Pg.121]

Z Chowhan, R Pritchard. Release of corticoids from oleaginous ointment bases containing drug in suspension. J Pharm Sci 64 754, 1975. [Pg.123]

Many attempts to alter the physical properties of neomycin by the formation of various salts have been described. Thus the neomycin salts of the higher fatty acids, such as the stearate, palmitate and myristate3(3 31 were prepared and being water-insoluble were formulated in ointment bases. Similarly, the undecylenate salt has been prepared and processes for its production patented3 33 34 The undecylenate and caprylate salts have been described as being particularly suitable as antimitotic compounds35. [Pg.415]

Simone and Popino have considered the stability of neomycin in both hydrophobic and hydrophilic ointment bases. No loss of potency over a period of 1 year at 20°C was reported for formulations containing carboxymethylcellulose, polyethylene glycol(P.E.G.) or white-soft paraffin. However, formulations containing hydrous lanolin were reported to be unstable. All materials used in the formulations were obtained from U.S. sources. Coates et al3°l investigated the use of P.E.G. from British sources and described neomycin as being incompatible with the materials tested. [Pg.425]

Florestano et al compared the release of neomycin from P.E.G. diester ointment bases and grease-type bases and concluded the former to be preferred though Coates et al Ol have described P.E.G. from British sources to be incompatible with neomycin. [Pg.426]

Ointments are semisolid preparations that are intended for external use. Ointments may contain either finely powdered drugs or their mixtures, liquids, and other drug forms incorporated into appropriate bases. They are applied to the skin for their physical effects as emollients (which make the skin more pliable), protectants, lubricants, and drying agents. Ointment bases are also used as vehicles in which to incorporate topical medications which exert specific effect. There are four types of ointment bases, namely, oleaginous, absorption, water removable, and water soluble bases. [Pg.138]

Vegetable drug extracts may be softened with alcohol before they are incorporated into ointment bases. [Pg.139]

What is the percentage of ophthalmic hydrocortisone ointment prepared by mixing 10 grams of 2.5% hydrocortisone ointment, 8 g of 2% hydrocortisone ointment, and 14 g of ointment base (diluent) ... [Pg.145]

From the following formula, calculate the quantity of each ingredient required to prepare 1 lb (avoir.) of the ointment base. [Pg.146]

When semisolid preparations of certain strength are diluted with ointment bases (also referred to as diluents), the strength of the mixture will be lowered. The percentage strength decreases as the quantity increases. To calculate the percent by weight strength of a semisolid mixture, an equation may be used as follows ... [Pg.147]

How many grams of the ointment base (diluent) should be used to make an ointment containing 5% of boric acid ... [Pg.148]

H. Loth, A. Holla-Benninger, and M. Hailer. Studies of the release of active agents from ointments. II. Effects of the quality of water-free ointment bases on the release of active agents from suspension ointments. Pharm. Ind. 41 789-796 (1979). [Pg.30]

Ointments and Creams Ointments are applied to the skin for topical treatment or to be absorbed into the blood system for delivery to target areas. They are semisofid preparations obtained by mixing the API with selected ointment bases depending on intended use. These bases include petrolatum, paraffin, mineral oil, lanolin, and glycols. Preservatives are often added to ensure the ointments will maintain the recommended shelf life. [Pg.350]

Ointments are semi-solid greasy preparation for local application to the skin, rectum and mucous membrane also. The ointment base is usually anhydrous and contain the medicaments in solution or suspension. Ointments are used for its soothing, astringent, antiseptic and other selected actions e.g. Chloromycetin eye ointment. [Pg.14]

A suitable negative product control for an aqueous product could be distilled water in a similar container. A negative product control for testing an ointment could be a container of liquid paraffin or ointment base that has been sterilized by dry heat pouring the liquid paraffin from a container would be adequate to simulate squeezing of ointment from a tube. [Pg.810]

Bacitracin is highly nephrotoxic when administered systemically and is only used topically (Chapter 62). Bacitracin is poorly absorbed. Topical application results in local antibacterial activity without systemic toxicity. Bacitracin, 500 units/g in an ointment base (often combined with polymyxin or neomycin), is indicated for the suppression of mixed bacterial flora in surface lesions of the skin, in wounds, or on mucous membranes. Solutions of bacitracin containing 100-200 units/mL in saline can be used for irrigation of joints, wounds, or the pleural cavity. [Pg.997]

Bacitracin and gramicidin are peptide antibiotics, active against gram-positive organisms such as streptococci, pneumococci, and staphylococci. In addition, most anaerobic cocci, neisseriae, tetanus bacilli, and diphtheria bacilli are sensitive. Bacitracin is compounded in an ointment base alone or in combination with neomycin, polymyxin B, or both. [Pg.1287]

Experimental studies on the percutaneous absorption of hydrocortisone fail to reveal a significant increase in absorption when applied on a repetitive basis and a single daily application may be effective in most conditions. Ointment bases tend to give better activity to the corticosteroid than do cream or lotion vehicles. Increasing the concentration of a corticosteroid increases the penetration but not proportionately. For example, approximately 1% of a 0.25% hydrocortisone solution is absorbed from the forearm. A 10-fold increase in concentration causes only a fourfold increase in absorption. Solubility of the corticosteroid in the vehicle is a significant determinant of the percutaneous absorption of a topical steroid. Marked increases in efficacy are noted when optimized vehicles are used, as demonstrated by newer formulations of betamethasone dipropionate and diflorasone diacetate. [Pg.1300]

Urea in a compatible cream vehicle or ointment base has a softening and moisturizing effect on the stratum corneum. It has the ability to make creams and lotions feel less greasy, and this has been utilized in dermatologic preparations to decrease the oily feel of a preparation that otherwise might feel unpleasant. It is a white crystalline powder with a slight ammonia odor when moist. [Pg.1303]

Ointment bases vehicles to permit topical application of active medicinal substances. [Pg.42]

Pastes may be defined as a semisolid dosage form that contains a large proportion (i.e., 20-50%) of solids finely dispersed in a fatty vehicle (basically an ointment base) for external application to the skin. The presence of a high concentration of solids makes them much stiffer than ointments. Like ointments, pastes form an unbroken... [Pg.203]

Velissaratou AS, Papaioannou G. In vitro release of chlorpheniramine maleate from ointment bases. Int J Pharma 1989 52(1) 83 86. [Pg.213]

Higuchi, T., Rate of release of medicaments from ointment bases containing drugs in suspension, J. Pharm. Sci., 50, 874, 1961. [Pg.633]

As another example, desonide and parabens in cream and ointment formulations were cleaned up by SPE by first testing mixtures of hexane-chloroform with silica, diol, and aminopropyl sorbents [36]. The solvent combination of 20% chloroform in hexane was found to be the optimum for dissolving the ointment base and yielding high recoveries of the analytes. The silica and aminopropyl sorbents were found to give nearly identical quantitative results, whereas the diol sorbent gave lower recoveries. Table 2.4 outlines the solvent considerations needed to elute retained compounds on silica and C,8 sorbents. [Pg.22]


See other pages where Base ointment is mentioned: [Pg.143]    [Pg.376]    [Pg.206]    [Pg.226]    [Pg.421]    [Pg.148]    [Pg.148]    [Pg.155]    [Pg.91]    [Pg.1287]    [Pg.654]    [Pg.203]    [Pg.236]    [Pg.1443]    [Pg.1443]    [Pg.620]    [Pg.123]   


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Hydrocarbon-based ointments

Ointment absorption bases

Ointment bases lanolin

Ointment bases lanolin alcohols

Ointment bases paraffin

Ointment bases petrolatum

Ointment bases polyethylene glycol

Ointment bases stearic acid

Ointment hydrocarbon bases

Ointment water-removable bases

Ointment water-soluble bases

Ointments

Paraffin anhydrous ointment bases

Paraffin based ointment

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