Intraperitoneally

Over the years animal studies have repeatedly shown that perfluorinated inert fluids are nonirritating to the eyes and skin and practically nontoxic by ingestion, inhalation, or intraperitoneal injection (17,22). Thermal degradation can produce toxic decomposition products including perfluoroisobutene which has a reported LC q of 0.5 ppm (6 hr exposure in rats) (31). This decomposition generally requires temperatures above 200°C. 

Acute Toxicity. Plasticizers possess an extremely low order of acute toxicity LD q values are mostiy in excess of 20,000 mg/kg body weight for oral, dermal, or intraperitoneal routes of exposure. In addition to thek low acute toxicity, many years of practical use coupled with animal tests show that plasticizers do not kritate the skin or mucous membranes and do not cause sensitization. 

The effect of pyrogaHol on algae has also been studied (27). Acute toxicity data include oral LD q (rat) = 789 mg/kg, intraperitoneal LD3Q (mouse) = 400 mg/kg, and oral LD q (rabbit) = 1600 mg/kg (28). 

Tolypomycin Y (48) shows strong antibacterial activity against gram-positive bacteria and Neisseriagonorrheae. When adininistered by subcutaneous, intraperitoneal, and intravenous routes, tolypomycin Y is effective in mice infected with Staphylococcus aureus Streptococcuspyrogenes and Diplococcuspneumoniae. Cross-resistance is observed with rifampicia but not with other antibiotics. Resistance to tolypomycin Y develops rapidly. The bioactivity of tolypomycin R... 

In Vivo Effects of Florfenicol. Comparative acute toxicities of florfenicol, chloramphenicol, and thiamphenicol in mice ate given in Table 6. As can be seen, florfenicol is similar to thiamphenicol in acute toxicity by oral and subcutaneous (sc) adininistration, but is comparable to chloramphenicol by intraperitoneal (ip) and intravenous (iv) routes. Semm levels in mice following either a single or subcutaneous dose of 200 mg/kg of amphenicol have... 

Toxicology. Isoquinoline is a poison when ingested or injected intraperitoneally. Even in cases of skin contact it is moderately toxic. As in the case of quinoline, its vapors are irritating to the eyes, nose, and throat. Exposure causes headaches, dizziness, and nausea. Rapid absorption through the skin makes it a dangerous chemical. Its toxicity is oral LD q (i t)> mg/kg, and dermal LD q (rabbit), 590 mg/kg (65,66,182,183). 

The toxicity of a few boric acid esters has been summarized (30). In general the toxicities are directiy related to the toxicity of the alcohol or phenol produced on hydrolysis. Methyl borate has an oral rat LD q of 6.14 mL/kg in a range finding test (31) and the percutaneous LD q for the rabbit of 1.98 mL/kg. In eadier work (32), the oral LD q for the rat was 2.82 mL/kg the intraperitoneal LD q was 3.2 mL/kg. It has been shown that the mouse is more susceptible to these compounds than the rat. Methyl borate was found to be moderately irritating in an ocular toxicity test using rabbits (31,32) but only mildly irritating to skin (31). 

Cobalt compounds can be classified as relatively nontoxic (33). There have been few health problems associated with workplace exposure to cobalt. The primary workplace problems from cobalt exposure are fibrosis, also known as hard metal disease (34,35), asthma, and dermatitis (36). Finely powdered cobalt can cause siUcosis. There is Htfle evidence to suggest that cobalt is a carcinogen in animals and no epidemiological evidence of carcinogenesis in humans. The LD q (rat) for cobalt powder is 1500 mg/kg. The oral LD q (rat) for cobalt(II) acetate, chloride, nitrate, oxide, and sulfate are 194, 133, 198, 1700, 5000, and 279 mg/kg, respectively the intraperitoneal LD q (rat) for cobalt(III) oxide is 5000 mg/kg (37). 

Dye name CAS Registry Number Oral LD q Dermal LD q Intraperitoneal LD q ... 

This LD q was derived from an intravenous injection and not an intraperitoneal injection. 

LD q values are for rat-oral (ingestion) except for diethyl phthalate which is rat-intraperitoneal. 

Hexachlorocyclotriphosphazene (cycHc trimer) is a respiratory irritant. Nausea has also been noted on exposure (10). Intravenous and intraperitoneal toxicity measurements were made on mice. The highest nonlethal dose (LDq) was measured as 20 mg/kg (11). Linear chloropolymer is also beUeved to be toxic (10). Upon organic substitution, the high molecular weight linear polymers have been shown to be inert. Rat implants of eight different polyphosphazene homopolymers indicated low levels of tissue toxicity (12). EZ has been found to be reasonably compatible with blood (13), and has lower hpid absorption than fiuorosihcone. 

Threshold limit value—time-weighted average. Intraperitoneal. 

Chloro-oxazolo[4,5-/i]quinoline-2-carboxylic acid methyl ester was the most active compound in tests for inhibitors of antigen-induced release of histamine in vitro from rat peritoneal mast cells (IC50 of 0.3 p,M) and as inhibitors of IgE-mediated passive cutaneous anaphylaxis in the rat (ED50 (intraperitoneal) of 0.1 mg/kg in dose 0.5 mg/kg as an inhibitor of the test)—10 times and 60 times more potent, respectively, than the disodium salt of cromoglycic acid (85JMC1255). 

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