Range-finding

The toxicity of a few boric acid esters has been summarized (30). In general the toxicities are directiy related to the toxicity of the alcohol or phenol produced on hydrolysis. Methyl borate has an oral rat LD q of 6.14 mL/kg in a range finding test (31) and the percutaneous LD q for the rabbit of 1.98 mL/kg. In eadier work (32), the oral LD q for the rat was 2.82 mL/kg the intraperitoneal LD q was 3.2 mL/kg. It has been shown that the mouse is more susceptible to these compounds than the rat. Methyl borate was found to be moderately irritating in an ocular toxicity test using rabbits (31,32) but only mildly irritating to skin (31). 

On pages 3 and 4, the calculations for Chapter 5.3 Range Finding Experiments are calculated for the example. The results listed on page 4 in line 38 are listed again in Table 5.3.1 and shown on Figures 5.3.2 and 5.3.3. 

Military uses for lasers are abundant, from range-finding to guided munitions to laser aiming devices on firearms. Warfare has been revolutionized by the laser. Law enforcement uses lasers to lift hard-to-recover fingerprints and in laser radar speed guns. 

FMC. 1980a. Final report Range-finding study with FMC 5462 in pregnant rats. Conducted for Food Machinery and Chemical Corporation. Raltech Scientific Services, Madison, WI. Raltech study no. 79031. 

Smyth HF, Carpenter CP, Weil CS, et al. 1969. Range-finding toxicity data. ListVll. Am Ind Hyg Assoc J 30 470-476. 

The method will now be tested in a ringtest by 8 dfferent laboratories in Europe. A preliminary range finding will be done in Vienna in October 1999. Test oganisms will be Stapylococus aureus and Pseudomonas aeruginosa, exposure time will be 5 minutes. The test surfaces will be stainless steel disks (2 cm diameter) with a specific finish. The problem of a standardized drying procedure was discussed. There was no decision about the number of replicates of the test. 

No fetal effects were noted in a dose range-finding developmental study in which pregnant Sprague-Dawley rats were exposed to 150 ppm hydrogen sulfide on gestation days 6-20, despite body weight loss in the dams (Saillenfait et al. 1989). 

The rate of the second order decomposition of acetaldehyde was measured over a temperature range. Find the activation energy and the frequency factor. 

Often, in range-finding tests, the endpoint is simply to determine what is the maximum dosage that can be given without killing an animal. There are numerous designs available for obtaining this information that minimize the expenditure of animals and other resources. 

Using Range-Finding Lethality Data in Drug Development ... 

Smyth, H. and Carpenter, C. (1944). The place of the range-finding test in the industrial toxicology laboratory. J. Indus. Hyg. Tox. 26 269-273. 

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