Ceftazidime intraperitoneal

Ceftazidime also can be used in patients undergoing intraperitoneal dialysis (IPD) and continuous ambulatory peritoneal dialysis (CARD). Give a loading dose of 1 g, followed by 500 mg every 24 hours. In addition to IV use, ceftazidime can be incorporated in the dialysis fluid at a concentration of 250... 

Neurotoxicity has been reported with intracerebroventricular cefazolin (12) and with systemic cefazolin (13-15), cefepime (16), cefotaxime (17-19), ceftazidime (20,21), and cefuroxime (22). Ceftazidime also caused truncal asterixis (23) and absence status and toxic hallucinations (24). Even the least epileptogenic of 15 cephalosporins, namely cefonicid (11), caused seizures (25), although this effect was disputed (26). As expected, seizures after systemic treatment were predominant in uremic patients, and neurotoxicity has been associated with intraperitoneal ceftazidime therapy in a patient... 

Schaefer F, Klaus G, Muller-Wiefel DE, Mehls O. Intermittent versus continuous intraperitoneal glycopep-tide/ceftazidime treatment in children with peritoneal dialysis-associated peritonitis. The Mid-European Pediatric Peritoneal Dialysis Study Group (MEPPS). J Am Soc Nephrol 1999 10(l) 136-45. 

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