Passive cutaneous anaphylaxis and

Arbortristoside A (4) and C (6) showed activity against passive cutaneous anaphylaxis and mast cells stabilizing activity [138]. This compound provided protection to mice against systemic infection of Candida albicans [139]. 

In vivo, RA has been reported to inhibit cobra venom factor (CVF)-induced paw edema, immune complex-mediated passive cutaneous anaphylaxis, and complement-dependent stimulation of prostacyclin synthesis. 

Chloro-oxazolo[4,5-/i]quinoline-2-carboxylic acid methyl ester was the most active compound in tests for inhibitors of antigen-induced release of histamine in vitro from rat peritoneal mast cells (IC50 of 0.3 p,M) and as inhibitors of IgE-mediated passive cutaneous anaphylaxis in the rat (ED50 (intraperitoneal) of 0.1 mg/kg in dose 0.5 mg/kg as an inhibitor of the test)—10 times and 60 times more potent, respectively, than the disodium salt of cromoglycic acid (85JMC1255). 

Fig. 2. IgG-mediated systemic versus local anaphylaxis, a IgG-mediated systemic anaphylaxis. When allergen-IgG immune complexes are formed in the circulation, basophils immediately capture them through IgG receptors on their surface and are activated to release PAF, that in turn act on vascular endothelial cells, leading to increased vascular permeability, b Passive cutaneous anaphylaxis. When allergen-IgG immune complexes are formed in the skin, they stimulate tissue-resident mast cells to release chemical mediators such as histamine, leading to local inflammation. 

Arimura A, Nagata M, Takeuchi M, Watanabe A, Nakamura K, Harada M Active and passive cutaneous anaphylaxis in WBB6F1 mouse, a mast cell-deficient strain. Immunol Invest 1990 19 227-233. 

The synthetic P-o-glucopyranoside 30 was converted to the cyanoglucoside rho-diocyanoside A (38a), which was isolated from the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. (Crassulaceae) and found to show antiallergic activity in a passive cutaneous anaphylaxis test in rat. Acetylation of 30 gave an acetate (98% yield) which was subjected to ozonolysis to afford the aldehyde 39. The Horner-Emmons reaction of 39 using diethyl (l-cyanoethyl)phosphonate furnished (Z)-40a (32% yield from 30) and ( )-40b (10% yield from 30). The physical... 

Amino-substituted naphthoquinones and heterocyclic variants have been disclosed in the patent literature as 5-LO inhibitors. Compounds represented by (80) (X = C, N) from Lilly inhibited SRS-A release from sensitized guinea-pig lung tissue [218]. Similar compounds such as (81) (R = carboxylic ester, acyl, or aryl) and related naphthalene derivatives, from American Cyanamid, gave good inhibition in guinea-pig ISN (at 10 //g/ml) and in passive cutaneous anaphylaxis in mice (25-60 /zM i.p.) [219,220]. 

Passive cutaneous anaphylaxis studies of byssinotic and nonbyssinotic sera in our laboratory and similar studies in rabbits... 

There are four subclasses of IgG IgGi, 70% IgGj, 16% IgG., 10%, and IgG, 4%. IgGi is capable of inhibiting IgE-mediated passive cutaneous anaphylaxis (PGA) reaction in baboons when injected in relatively high concentrations. 

Hexahydropyrimido[l,2-a]azepin-4-ones 456, 463, and 467 display analgetic activity (77MI1). 10-Aminomethylene and 10-phenylhydrazino derivatives 478 (R = H) possess weak antiallergic effects in the passive cutaneous anaphylaxis (PCA) test (84JMC1253). 

Typical protocols for dermal sensitization, active systemic anaphylaxis, and passive cutaneous anaphylaxis tests are given in the article Animals in Drug Development, in this encyclopedia. In a typical gel-diffusion test, solutions of test compound, egg albumin (positive control), or vehicle (usually saline) are mixed with complete Freund s adjuvant. These mixtures are injected into animals (usually guinea pigs) of the... 

In addition to these chemotherapeutic indications, some pharmacodynamic uses are indicated. 4-Amino-3-o-chlorobenzyltriazole-5-carboxamide and related compounds are claimed as useful anticonvulsants (84JAP118775). 5-Butoxycarbonyl-2-(Af-3-piperidinopropyl)-4-p-toluidinotriazole (89) is claimed as a potent vasodilator (83GEP3134842). lH-Triazolo[4,5-b]quinol-4-one (99) is claimed to inhibit passive cutaneous anaphylaxis in rats and to be of interest in treating human asthma [80EUP(A)2562]. 

Inagaki, N., Miura, T., Daikoku, M., Nagai, H. and Koda, A. (1989). Inhibitory effects of jS-adrenergic stimulants on increased vascular permeability caused by passive cutaneous anaphylaxis, allergic mediators, and mediator releasers in rats. Pharmacology 39, 19-27. 

Structure activity relationships for a series of chromone-2-carboxylic acids, of which FPL 52791 (21) showed efficacy in passive cutaneous anaphylaxis (PCA) (rat) both by intravenous and oral administration, have been published. Substitution in ring A shows that 6,8-di-t-butyl (12 x DSCG)>6,8-di-Et>6,8-di-Me monosubstitution.7 Clinical studies of 21 are in progress. Similarly, in a series of chromones with a tetrazolyl moiety at the 2 or 3 position, (22) was the most potent in the PCA (rat), both orally and i.v. (—11.6 x DSCG). The following structure activity relationships were noted (a) the 3-tetrazolyl... 

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