Penicillin intraperitoneal

SAFETY PROFILE Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx. See other penicillin entries. 

In a great many cases the level of free drug in the tissue fluids eventually becomes the same as that in the plasma. This relationship is convenient because the plasma is more accessible for analysis. Among examples investigated are the anti-bacterial sulfonamide, sulfadoxine ( Fanasil ) in the intraperitoneal cavity of rats after oral injection (McQueen, 1968), also various penicillins in lymph of dogs. The literature of this correlation has been reviewed by Robinson (1966). 

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