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Antitumor activity against intraperitoneally

It was observed that macbecins I (93) and II (94) were moderately active against several Gram-positive bacteria and fungi, [149,205] whereas macbecin I (93) exhibited marked antitumor activity against intraperitoneally (ip) inoculated leukemia P388, B16 melanoma and Ehrlich s carcinoma in mice on ip administration [152]. According to this report, the maximum effect measured in terms of ILS (increase of life span) was 97% at a daily dose level of 10 mg/kg for leukemia P388, 103% at 5... [Pg.96]

In Vivo Antitumor Properties. Initial studies using intraperitoneal administration of AMD473 at doses of 35-40 mg/kg showed the drug to confer marked antitumor activity against both murine (ADJ/PC6, cf. Table) and human ovarian-carcinoma xenografts [54]. Moreover, activity was observed... [Pg.515]

Significant in vivo antitumor activity by both the intraperitoneal and oral routes against acquired cisplatin-resistant human ovarian-carcinoma xenografts ... [Pg.517]

Antitumor activity was tested against subcutaneously implanted Sarcoma 180 in mice. Daily intraperitoneal treatment was started 24 h after tumor implantation, and the results were recorded after 5 weeks. [Pg.263]

See other pages where Antitumor activity against intraperitoneally is mentioned: [Pg.74]    [Pg.74]    [Pg.124]    [Pg.246]    [Pg.1157]    [Pg.133]    [Pg.233]    [Pg.73]    [Pg.257]    [Pg.348]    [Pg.1059]    [Pg.33]    [Pg.282]    [Pg.203]    [Pg.397]    [Pg.279]    [Pg.140]    [Pg.25]    [Pg.282]    [Pg.161]    [Pg.119]    [Pg.570]    [Pg.248]   


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Antitumor activity

Antitumoral activity

Intraperitoneal

Intraperitoneally

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