Glioma

Zhong, H., Guerrero, S. W., Esbenshade, T. A., and Minneman, K. P. (1996). Inducible expression of 3 - and P2-adrenergic receptors in rat C6 glioma cells Functional interactions between closely related subtypes. Mol. Pharmacol. 50 175-184. [Pg.98]

Kim Y, Yoon JW, Xiao X et al (2007) Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res 67(8) 35 83-3593... [Pg.189]

Reports of ChE abnormalities in tumours, e.g., meningioma, glioma, acoustic neurinomas and lung cancers, megakaryocytopoietic disorders and leukemias, ovarian tumours and neuroblastomas, suggest cell proliferation and differentiation activities. [Pg.358]

AP 12009 Antisense oligonucleotide TGF- 32 Glioma, pancreatic carcinoma, melanoma... [Pg.1232]

The transmissible spongiform encephalopathies, or prion diseases, are fatal neurodegenerative diseases characterized by spongiform changes, astrocytic gliomas, and neuronal loss resulting from the deposition of insoluble protein aggregates in neural cells. They include Creutzfeldt-Jakob disease in humans, scrapie in... [Pg.37]

In addition to their inherent self-sustaining properties, brain tumor stem cells may be more resistant to chemotherapy and radiation therapy than other tumor cells. Bao et al. (2006) found glioma stem cells (CD133+) were relatively radioresistant compared to CD133- tumor cells and preferentially activated the DNA damage checkpoint response. This relative resistance to standard treatment approaches of tumor stem cells compared to the majority of other cells within a tumor may underlie our current inability to cure patients with aggressive brain tumors such as glioblastoma. [Pg.257]

CCR4-expresssing regulatory T cells is also stimulated via glioma cell secretion of CCL2. This may be an important mechanism whereby gliomas suppress anti-tumor immune responses and evade immune detection (Jordan et al. 2008). [Pg.265]

Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, HerrUnger U, Ourednik V, Black PM et al (2000) Neural stem cells display extensive tropism for pathology in adult brain evidence from intracranial gliomas. Proc Natl Acad Sci USA 97 12846-12851... [Pg.266]

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444 756-760... [Pg.266]

Birnbaum T, Roider J, Schankin CJ, Padovan CS, Schichor C, Goldbrunner R, Straube A (2007) Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines. J Neurooncol 83 241-247... [Pg.266]

Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL, Yu JS (2002b) The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 62 5657-5663... [Pg.267]

Ehtesham M, Winston JA, Kabos P, Thompson RC (2006) CXCR4 expression mediates glioma cell invasiveness. Oncogene 25 2801-2806... [Pg.267]

Ping YF, Yao XH, Chen JH, Liu H, Chen DL, Zhou XD, Wang JM, Bian XW (2007) The anticancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells. J Neurooncol 84 21-29 Pitcher JA, Freedman NJ, Lefkowitz RJ (1998) G protein-coupled receptor kinases. Annu Rev Biochem 67 653-692... [Pg.269]

Tabatabai G, Frank B, Mohle R, Weller M, Wick W (2006) Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-lalpha-mediated induction of CXCL12. Brain 129 2426-2435... [Pg.270]

Warrington NM, Woemer BM, Daginakatte GC, Dasgupta B, Perry A, Gutmaim DH, Rubin JB (2007) Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1. Cancer Res 67 8588-8595... [Pg.270]

Zagzag D, Lukyanov Y, Lan L, Ah MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma implications for angiogenesis and glioma cell invasion. Lab Invest 86 1221-1232... [Pg.270]

Zhang J, Sarkar S, Yong VW (2005) The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase. Carcinogenesis 26 2069-2077... [Pg.270]

Zhou Y, Zhang J, Liu Q, Bell R, Muruve DA, Forsyth P, Arcellana-Panliho M, Robbins S, Yong VW (2005) The chemokine GRO-alpha (CXCLl) confers increased tumorigenidty to glioma cells. Carcinogenesis 26 2058-2068... [Pg.270]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...