Glioma cells

Zhong, H., Guerrero, S. W., Esbenshade, T. A., and Minneman, K. P. (1996). Inducible expression of 3 - and P2-adrenergic receptors in rat C6 glioma cells Functional interactions between closely related subtypes. Mol. Pharmacol. 50 175-184. 

CCR4-expresssing regulatory T cells is also stimulated via glioma cell secretion of CCL2. This may be an important mechanism whereby gliomas suppress anti-tumor immune responses and evade immune detection (Jordan et al. 2008). 

Ehtesham M, Winston JA, Kabos P, Thompson RC (2006) CXCR4 expression mediates glioma cell invasiveness. Oncogene 25 2801-2806... 

Ping YF, Yao XH, Chen JH, Liu H, Chen DL, Zhou XD, Wang JM, Bian XW (2007) The anticancer compound Nordy inhibits CXCR4-mediated production of IL-8 and VEGF by malignant human glioma cells. J Neurooncol 84 21-29 Pitcher JA, Freedman NJ, Lefkowitz RJ (1998) G protein-coupled receptor kinases. Annu Rev Biochem 67 653-692... 

Zagzag D, Lukyanov Y, Lan L, Ah MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma implications for angiogenesis and glioma cell invasion. Lab Invest 86 1221-1232... 

Zhou Y, Zhang J, Liu Q, Bell R, Muruve DA, Forsyth P, Arcellana-Panliho M, Robbins S, Yong VW (2005) The chemokine GRO-alpha (CXCLl) confers increased tumorigenidty to glioma cells. Carcinogenesis 26 2058-2068... 

Bohn LM, Belcheva MM, Coscia CJ (2000) p-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J Neurochem 74 574-581... 

Martin DL, Shain W (1979) High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells. J Biol Chem 254(15) 7076-7084... 

Zhou Y, Larsen PH, Hao C, Yong VW. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 2002 277 49481-7. 

Bajetto A, Barbieri F, Dorcaratto A, et al. Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues role of CXCR4 and SDF1 in glioma cell proliferation and migration. Neurochem Int 2006 49 423—432. 

Mackie K, Hille B. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc Natl Acad Sci 1992 89 3825-3829. 

Tonner LE, Katz DI, Heiman AS. 1997. The acute effect of lead acetate on glucocorticoid receptor binding in C6 glioma cells. Toxicology 116 109-122. 

Nakatani K, Norimichi N, Tsutomu A, Hideyuki Y, Yasushi O. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by -y-mangostin, a xanthone derivative in man-gosteen, in C6 rat glioma cells. Biochem Pharmacol 2002 63 73-79. 

BNCT sensitisers are designed with neutron capture in mind, but those that are porphyrin/ phthalocyanine-based may show PDT activity. An example is the disodium (or dipotassium) salt of the tetrakis-carborane ester (58) derived from 3,8-bis(l,2-dihydroxyethyl)deuteroporphyrin.298 This is water soluble and tumor selective, showing high tumor/normal brain ratios.299 Photophysical properties are similar to other water-soluble porphyrins in rat glioma cells, specific localization in mitochondria is observed.300... 

Helmeste, D.M., Hammonds Jr., R.G., and Li, C.H. (1986) Preparation of [125I-Tyr27, Leu5]bh-endor-phin and its use for cross-linking of opioid binding sites in human striatum and NG108-15 neuroblastoma-glioma cells. Proc. Natl Acad. Sci. USA 83, 4622 1625. 

Bouzier, A. K., Voisin, R, Goodwin, R. etal. Glucose and lactate metabolism in C6 glioma cells evidence for the preferential utilization of lactate for cell oxidative metabolism, Dev. Neurosci. 20 331-338,1998. 

Investigations of the cellular effects of radiofrequency radiation provide evidence of damage to various types of avian and mammalian cells. These effects involve radiofrequency interactions with cell membranes, especially the plasma membrane. Effects include alterations in membrane cation transport, Na+/K+-ATPase activity, protein kinase activity, neutrophil precursor membrane receptors, firing rates and resting potentials of neurons, brain cell metabolism, DNA and RNA synthesis in glioma cells, and mitogenic effects on human lymphocytes (Cleary 1990). 

Fagan KA, Mons N Cooper DMF 1998 Dependence of the Ca2+-mhibitable adenylyl cyclase of C6-2B glioma cells on capacitative Ca2+ entry. J Biol Chem 273 9297—9305 Fierro L, Parekh AB 2000 Substantial depletion of the intracellular Ca2+ stores is required for macroscopic activation of the Ca2+ release-activated Ca2+ current in rat basophilic leukaemia cells. J Physiol 522 247—257... 

In mouse glioma cells, many kinds of changes in cell organelles after exposure to 5 x 10 5 M mercuric chloride in vitro could be found [ 144]. Nuclei showed pyknotic and irregular shapes mitochondria lost their normal cristae and abnormal electron-dense areas were present within the matrix polyribosomes were dispersed. Numerous electron-dense granules and vacuolations were seen in the cytoplasm, especially around the Golgi region,... 

Brasuel M, Kopelman R, Miller TJ, Tjalkens R, Philbert MA (2001) Fluorescent nanosensors for intracellular chemical analysis decyl methacrylate liquid polymer matrix and ion-exchange-based potassium PEBBLE sensors with real-time application to viable rat C6 glioma cells. Anal Chem 73 2221-2228... 

Zhang W, Law RE, Hinton DR, Couldwell WT. (1997). Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. Cancer Lett. 120(1) 31-8. 

Chang, G.H., Barbara, N.M., and Pieper, R.O., 2000, Phosphatidylserine-dependent phagocytosis of apoptotic cells by normal human microgha, astrocytes, and glioma cells, Neuro-oncol. 2 174-183. 

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