Subcutaneous glioma

In the same model of subcutaneous glioma, there has been recent work to inject, this time intravenously, LNC loaded with ferrocidiphenol 15 and coated with long PEG chains. The coating of the nanocapsules allows the LNC to remain longer in the bloodstream than conventional LNC, and thus to enhance accumulation in tumors through the EPR (enhanced permeability and retention) effect. Indeed, tumoral progression curves show a marked reduction in the size of tumors in treated rats. After several days, the tumor volume diminishes significantly to the point of disappearance at the end of the experimental period [156]. 

Elsayed et al. (1992) performed subcutaneous injections of GEES that resulted in increased GST activity, increased lipid peroxides, and depleted, reduced GSH in lung tissue (Elsayed et al., 1992). Similar findings occurred in the in vitro mouse model, a neuroblastoma-rat glioma hybrid cell line, in that there was a reduction in GSH as a function of time after exposure (Moore and Ray, 1983). Within the last 5 years, there has been a greater emphasis on the inhalation effects of SM. 

Cope DA et al. Enhanced delivery of a monoclonal antibody F(ab )2 fragment to subcutaneous human glioma xenografts using local hyperthermia. Cancer Research 1990 50 1803-1809. 

The function of the ER domains is to silence the enzymatic activity of the luciferase. The construct was then stably transfected into human glioma (D54) cells and the cells constitutively expressing ER-DEVD-Luc-DEVD-ER were grown in cell culture and subcutaneous tumors were implanted in athymic... 

Ma, J. Li, S. Reed, K. Guo, P. Gallo, J.M. Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tmnor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models, J.Pharmacol.Exp.Ther., 2003,305, 833-839. [plasma rat]... 

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