Nervous system tumors gliomas

Malignant neoplasms of the nervous system occur with an incidence of 5-6/ 100,000 inhabitants/year [197], Besides meningeomas cerebral gliomas are the most frequent primary brain tumors. Primary treatment comprises surgical resection, irradiation and chemotherapy. However, survival and quality of life are still limited. For the diagnosis and differential diagnosis of brain tumors. 

Neurofibroma may occur as a sporadic tumor or as part of the dominantly inherited tumor syndrome called von Recklinghausen disease or neurofibromatosis-1 (NF-l).i Plexiform neurofibromas are multiple swollen fascicles that are associated with NF-1. Other nervous system signs of NF-1 are more than one neurofibroma, optic nerve glioma (more appropriately called optic nerve pilocytic astrocytoma), and malignant peripheral nerve sheath tumor with glandular or rhabdomyoblastic regions. ... 

Because of their highly lipophilic nature, nitrosoureas are particularly useful against malignancies of the central nervous system such as brain tumors (gliomas), where response rates have exceeded 40%. They are also used (in combination therapy) against multiple myeloma, Hodgkin s disease, and non-Hodgkin s lymphoma. 

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