Gliomas gliosis

CFAP/Dako/1 6400 Gliosis gliomas CNS parenchyma Ventana protease 2, 16 min... 

Epilepsy Low-grade glioma or ganglioglioma gliosis or vascular malformation GFAP neurofilament elastin Cerebral cortex... 

Because the hemangioblastoma is nonfibrillar, it should not resemble an astrocytoma. However, the resemblance may occur for two reasons sampling and artifact. Cerebellar hemangioblastomas are often cystic, with the actual neoplasm embedded somewhere in the wall of the cyst as a mural nodule. Biopsy specimens of the cyst wall may show conspicuously GFAP-positive gliosis (see the Gliosis versus Glioma section later in this chapter). 

Demyelination may be confused with neoplastic disease because it produces abundant gliosis. Large cells with short chromosomes spread apart in their cytoplasm mimic mitotic activity in a glioma.If numerous lipidladen KPl-positive macrophages are encountered within parenchyma and around vessels, demyelinating disease should be considered. Appropriate stains for myelin, NF stain for axons (see Box 20.2), and features described in this section should be considered in the interpretation (see Figs. 20.3A, 20.11 A and B, and 20.60). 

Gliomas expand, but gliosis contracts. This important feature is difficult to confirm without serial radiographs and in situ observation of the confluence of the actual mass and its margin to exclude the possibility of gliosis around another tumor. 

Another important feature distinguishing the margin of a glioma from gliosis is cellular density (see Table... 

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