C6 rat glioma cell line

In vitro studies on OP-induced neurotoxicity effects on glia have been conducted with the C6 rat glioma cell line as well as several primary culture types. C6 cells were derived from a rat brain tumor induced by Af-nitrosomelhylurca (Benda et ai, 1968). These cells display properties of... 

Rat kidney cells adapted to growth in 5 and 10//M Pb(N03)2 become resistant to challenge with otherwise toxic Pb(II) concentrations. This resistance is associated with de novo protein synthesis. A large number of new proteins are synthesized within 6h after the cells are exposed to Pb(II) (Hitzfeld et al. 1989). The C6 rat glioma cell line also shows an adaptive response to lead (Lake et al. 1980) and a similar response has been reported for human cells (Skreb et al. 1981). We have recently identified an inducible mechanism for arsenite resistance, with cross-resistance to arsenate and antimonite, in Chinese hamster V79 cells (Wang and Rossman 1993). This inducible response is different from the heat shock response (Wang et al. 1994). The reader is referred to Chaps. 10, 14, 15, and 17 in this volume for more information on metal-induced responses. 

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