Stromal cell—derived factor 1 SDF

Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 1996 184 1101-9. 

Hodohara K, Fujii N, Yamamoto N, Kaushansky K. Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of mega-karyocytic progenitor cells (CFU-MK). Blood 2000 95(3) 769-775. 

Valenzuela-Femandez A, Planchenault T, Baleux F, et al. Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4. J Biol Chem 2002 277(18) 15677-15689. 

Kanbe K, Takemura T, Takeuchi K, Chen Q, Takagishi K, Inoue K. Synovectomy reduces stromal-cell-derived factor-1 (SDF-1) which is involved in the destruction of cartilage in osteoarthritis and rheumatoid arthritis. J Bone Joint Surg Br 2004 86(2) 296-300. 

List some of the roles of stromal cell-derived factor 1 (SDF-1) in CNS development and homeostasis. 

Pan J, Mestas J, Burdick M, etal. (2006) Stromal cell derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer DOI 10.1186/1476-4598-5-56... 

Sadir, R., Imberty, A., Baleux, F., Lortat-Jacob, H. (2004). Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV. The Journal of Biological Chemistry, 279(42), 43854-43860. http //dx.doi.org/10.1074/jbc.M405392200. 

Seisdedos, F., and Emilie, D. (1999) Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis expression of SDF-1 hy mesofhelial cells and hiliary ductal plate epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, 96, 8585-8590. 

Shirozu, M., Nakano, T., Inazawa, J., Tashiro, K., Tada, H., Shinohara, T., and Honjo, T. (1995) Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF-1) gene. Genomics 28, 495-500. 

The first evidence that hinted at the link between chemokines and hematopoiesis was obtained from a gene knockout study where the gene for stromal cell-derived factor-1 (SDF-1, also called PBSF-1/CXCL12) was deleted (Nagasawa et al., 1996 Ma et al., 1998 Zou et al., 1998). CXCL12... 

Dunussi-Joannopoulos, K., Zuberek, K., Runyon, K., Hawley, R. G., Wong, A., Erickson, J., Herrmann, S., and Leonard, J. P. (2002). Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1) Local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses. Bloodim, 1551-1558. 

Another aspect of ECM related to both biospecific and physical characteristics of ECM concerns the formation of gradients of any of the above-listed signals to direct cellular behavior. Such gradients are, for instance, key to the signalling of chemokines such as stromal cell-derived factor-1 (SDF-1) for the... 

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