Cancer therapy glioma

Prasaana, P., Thibault, A., Liu, L. Sami D. (19%). J. Neurochem. 66 710-716. Lipid metabolism as a target for brain cancer therapy Synergistic activity of lovastatin and sodium phenylacetate against human gliomas. 

Chen TC,SuS, FryD,Liebes L (2003) Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma. Cancer 97 2363-2373... 

Curran WJ, Scott CB, Horton J, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 1993 85 704-710. 

Werner-Wasik M, Scott CB, Nelson DF, et al. Final report of a Phase I/II trial of hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas Radiation Therapy Oncology Group study 83-02. Cancer 1996 77 1535-1543. 

Schreiber S, Gross S, Brandis A, et al. Local photodynamic therapy (PDT) of rat C6 glioma xenografts with Pd-bacteriopheophorbide leads to decreased metastases and increase of animal cure compared with surgery. Int J Cancer 2002 99 279-85. 

The oncolytic viruses include adenovirus, measles, reovirus, vesicular stomatitis virus (VSV),HSV,poxvirus, and vaccinia. Specific examples include (1) ONYX-015, which is an adenoviral oncolytic virus, administered to patients with liver metastases of colorectal cancer and pancreatic cancer [29], (2) Reolysin, which is an oncolytic reovirus administered to patients with glioma [30], and (3) MV-CEA, which is an oncolytic measles virus expressing carcinoembryonic antigen, administered to patients with ovarian cancer [31]. Some oncolytic viruses are wild type and are apparently not pathogenic in humans, such as the Newcastle disease virus (NDV), which is an RNA avian paramyxovirus. PV701, a naturally attenuated, replication-competent strain of NDV, has been administered to patients with advanced solid tumors [32], The applicability of oncolytic viruses as a therapy for clinical oncology trials is due to their potential selectivity the ability to kill tumor cells but not normal cells. However, the level of attenuation of viral replication in normal cells is limited for most oncolytic vectors. 

Wikstrand, C. J., Cokgor, L, Sampson, J. H., and Bigner, D. D. (1999), Monoclonal antibody therapy of human gliomas Current status and future approaches, Cancer Metastasis Rev., 18, 451-464. 

Nicholas MK, Lukas RV, Jafri NF, Faoro L, Salgia R (2006) Epidermal growth factor receptor -mediated signal transduction in thedevelopment and therapy of gliomas. Clin Cancer Res 12 7261-7270... 

Leff RS, Thompson JM, Daly MB, Johnson DB, Harden EA, Mercier RJ, Messerschmidt GL. Acute neurologic dysfunction after high-dose etoposide therapy for malignant glioma. Cancer 1988 62(l) 32-5. 

Rat and human NIS was cloned and characterized in 1996. One of the approaches to increase the expression of NIS is gene transfer. Many studies have investigated the effect of NIS transfer on radioiodine therapy (Lee et al., 2004 Spitzweg et al., 2003), and NIS transfection via a viral vector has been shown to induce iodide uptake in several human nonthyroid tumor cell lines and xenografts, including gliomas, prostate cancer, ovarian cancer and colon cancer (Mandell et al., 1999 Cho et al., 2000). 

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