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Metalloproteinases matrix

There is abundant evidence that a diverse array of pro-teinases, particularly those of macrophage or leucocyte origin, have a fundamental role in the injury processes associated with diseases such as ai-antitrypsin deficiency, smoking-related emphysema, cystic fibrosis, bronchiectasis, bronchitis and other respiratory syndromes (Karlinsky and Snider, 1978 Stockley, 1983 Senior and Campbell, 1983 Surer etal., 1984 Janoff, 1985 Snider etal., 1991). However, there has been little exploration of their potential involvement in other airway disorders that have an inflammatory cell aetiology, such as certain types of specialized fibrotic disorders including chronic severe asthma. This is particularly true for the matrix metalloproteinases (MMPs), despite the expectation from their individual substrate specificities (Emonard and [Pg.197]

Grimaud, 1990) that they should be of fundamental importance in diseases associated with remodelling and fibrosis of the basement membrane, epithelial injury and fibrosis. [Pg.197]


Design and therapeutic application of matrix metalloproteinase heterocyclic inhibitors 99CRV2735. [Pg.232]

Vascular Indothelial Growth Factor Matrix Metalloproteinases... [Pg.88]

Activation of matrix metalloproteinases (MMP) is also involved in vascular and cardiac remodelling. For example, the fibrillar collagen matrix of the heart... [Pg.474]

Matrix Metalloproteinases Tumor Necrosis Factor Apoptosis... [Pg.494]

Matrix Metalloproteinases. Table 1 MMPs and their genes known so far... [Pg.746]

Matrix Metalloproteinases. Figure 1 Domain organization of different mammalian MMPs. [Pg.747]

Matrix Metalloproteinases. Figure 2 ProMMP-2-TIMP-2 structure (adopted from [4]). TIMP-2 cartoon and transparent surface structure is shown in blue, MMP-2 in red. The C-terminal ends of both molecules are marked as spheres. [Pg.747]

Somerville RP, Oblander SA, Apte SS (2003) Matrix metalloproteinases old dogs with new tricks. Genome Biol 4 216... [Pg.748]

Stetler-Stevenson WG (1999) Matrix metalloproteinases in angiogenesis a moving target for therapeutic intervention. J Clin Invest 103 1237-1241... [Pg.748]

Morgunova E, Tuuttila A, Bergmann U et al (2002) Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2. Proc Natl Acad Sci USA 99 7414—7419... [Pg.748]

The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitor of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form. [Pg.1201]

Matrix Metalloproteinases Matrix-assisted Laser Desorption/Ionization Mass Spectrometry... [Pg.1496]

Fig. 20 Modular resilin-like polypeptide containing domains conferring elastomeric properties, heparin molecule interaction, cell adhesion, and matrix metalloproteinase (MMP) proteolysis. Lysine residues are encoded periodically to permit crosslinking... Fig. 20 Modular resilin-like polypeptide containing domains conferring elastomeric properties, heparin molecule interaction, cell adhesion, and matrix metalloproteinase (MMP) proteolysis. Lysine residues are encoded periodically to permit crosslinking...
Lutolf MP, Lauer-Fields JL, Schmoekel HG et al (2003) Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration Engineering cell-invasion characteristics. Proc Natl Acad Sci 100 5413-5418... [Pg.167]

McQuibban GA, Butler GS, Gong JH, Bendall L, Power C, Clark-Lewis I, Overall CM (2001) Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem 276 43503 3508... [Pg.47]

Cox JH, Dean RA, Roberts CR et al (2008) Matrix metalloproteinase processing of CXCLl 1/I-TAC results in loss of chemoattractant activity and altered glycosaminoglycan binding. J Biol Chem... [Pg.167]

Gelman BB, Wolf DA, Rodriguez-Wolf M et al (1997) Mononuclear phagocyte hydrolytic enzyme activity associated with cerebral HIV-1 infection. Am J Pathol 151 1437-1446 Giraudon P, Buart S, Bernard A et al (1997) Cytokines secreted by gUal cells infected with HTLV-I modulate the expression of matrix metalloproteinases (MMPs) and their natural inhibitor (TIMPs) possible involvement in neurodegenerative processes. Mol Psychiatry 2(107-10) 84... [Pg.168]


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