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Drug transporter

In addition to drug-metabolizing enzymes, transporters play an important role in drug disposition and clearance. There are over 48 active ATP-binding cassette transporters in humans, and many more passive or facilitative transporters that play key roles in transporting endogenous and xenobiotic substrates. Key roles of transporters in drug pharmacokinetics [Pg.306]

Another important efflux transporter that has significant substrate specificity and functional redundancy with PgP is [Pg.306]


Essex J W, C A Reynolds and W G Richards 1989. Relative Partition Coefficients from Partition Functions A Theoretical Approach to Drug Transport. Journal of the Chemical Society Chemical Communications 1152-1154. [Pg.650]

Taken together ABC-transporters represent a large family of proteins affecting the pharmacokinetic parameters of various drugs. Here, P-gp is currently the best characterized member and it may also be one of the most important ABC-transporters with regard to drug transport. However, it becomes more and more apparent that ABC-transporter act in a coordinated... [Pg.7]

Chan LM, Lowes S, Hirst BH (2004) The ABCs of drug transport in intestine and liver efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 21 25—51... [Pg.8]

Permeation of a drug through biological membranes against the electrochemical gradient. This type of drug transport requires energy produced by intracellular metabolic processes. [Pg.14]

Ertl P, Rohde B, Selzer P. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. I Med Chem 2000 43 3714-7. [Pg.465]

Mao Q and Unadkat JD. Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J 2005 7 E118-33. [Pg.511]

Limtraknl, P. et al.. Modulation of the function of three ABC drug transporters, P-glycoprotein (ABCBl), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCCl) by tetrahydroenrenmin, a major metabolite of cur-enmin. Mol. Cell Biochem., 296, 85, 2007. [Pg.146]

The importance of drug ionization using cell-based methods such as Caco-2 in the in vitro prediction of in vivo absorption was discussed [45]. It was observed that when the apical pH used in Caco-2 studies was lowered from 7.4 to 6.0 a better correlation was obtained with in vivo data, demonstrating that careful selection of experimental conditions in vitro is crucial to produce a reUable model. Studies with Caco-2 monolayers also suggested that the ionic species might contribute considerably to overall drug transport [46]. [Pg.32]

Palm, K., Luthman, K., Ros, J., Grasjo, J., Artursson, P. Effect of molecular charge on intestinal epithelial drug transport pH-dependent transport of cationic drugs. J. Pharmacol. Exp. Ther. 1999, 293, 435-443. [Pg.45]

Osterberg, Th., Norinder, U. Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics. J. Chem. Inf. Comput. Set. 2000, 40, 1408-1411. [Pg.47]

Camenisch, G., Folkers, G., Van de Waterbeemd, H. Comparison of passive drug transport through Caco-2 cells and artificial membranes. Int. J. Pharm. 1997, 147, 61-70. [Pg.47]

Stewart, B. H., Chan, O. H. Use of immobilized artifidal membrane chromatography for drug transport applications. /. Pharm. Sci. 1998, 87, 1471-1478. [Pg.48]

Norinder, U., Osterberg, Th. The applicability of computational chemistry in the evaluation and prediction of drug transport properties. Perspect. Drug Discov. Des. 2000, 19, 1-18. [Pg.49]

Permeability-pH profiles, log Pe - pH curves in arhficial membrane models (log Pjpp - pH in cehular models), generally have sigmoidal shape, similar to that of log Dod - pH cf. Fig. 3.1). However, one feature is unique to permeabihty profiles the upper horizontal part of the sigmoidal curves may be verhcally depressed, due to the drug transport resistance arising from the aqueous boundary layer (ABL) adjacent to the two sides of the membrane barrier. Hence, the true membrane contribution to transport may be obscured when water is the rate-limiting resistance to transport. This is especially true if sparingly soluble molecules are considered and if the solutions on either or both sides of the membrane barrier are poorly stirred (often a problem with 96-well microhter plate formats). [Pg.74]

Norinder, U., Osterberg, T. Theoretical calculation and prediction of drug transport processes using simple parameters and partial least squares projections to latent structures (PLS) statistics. The use of electrotopological state indices./. Pharm. Sci. 2001, 90, 1075-1085. [Pg.107]

To our knowledge only in a single publication [18] was a better correlation of PSA with drug transport reported after inclusion of S fragments. [Pg.126]

Artursson, P., Palm, K., Luthman, K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug. Ddiv. Rev. 2001, 46, 27-43. [Pg.434]

Ishikawa, T., Onishi, Y., Hirano, H. et al. (2004). Pharmacogenomics of drug transporters a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDRl). Biol. Pharm. Bull., 27, 939 48. [Pg.166]


See other pages where Drug transporter is mentioned: [Pg.5]    [Pg.92]    [Pg.299]    [Pg.535]    [Pg.167]    [Pg.30]    [Pg.46]    [Pg.98]    [Pg.113]    [Pg.113]    [Pg.114]    [Pg.115]    [Pg.152]    [Pg.728]    [Pg.729]    [Pg.742]    [Pg.747]    [Pg.758]    [Pg.804]    [Pg.319]    [Pg.1267]    [Pg.3]    [Pg.170]    [Pg.48]    [Pg.435]   
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See also in sourсe #XX -- [ Pg.7 ]




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A Systems Biology View of Drug Transporters

ABC Drug Transporters of Human Fungal Pathogens

Active transport drug design

Acyclovir drug transport

Automation, drug transporter

Automation, drug transporter evaluation

Biological Membranes and Drug Transport

Blood brain barrier drug efflux transport systems role

Buccal absorption drug transport mechanism

CNS-Transporters as Drug Targets

Caco-2 drug transport assays

Carrier-mediated transport of drugs

Case II drug transport with axial and radial release from a cylinder

Cell culture models drug transport studies

Concentrative drug transport

Desolvation drug transport

Determination of Drug Transmembrane Transport

Distribution Drug Transport

Drug Efflux Transporters

Drug Metabolizing Enzymes and ABC Transporter

Drug Transport Mediated by ABC Transporters Using Eukaryotic Membrane Vesicles

Drug Transport Mediated by ABC Transporters Using Membrane Vesicles from Insect Cells

Drug Transport Mediated by SLC Transporters Using Eukaryotic Cells

Drug Transport Mediated by SLC Transporters Using Xenopus Laevis Oocytes

Drug Transport Mediated by SLC and ABC Transporters Using Double Transfected Cells

Drug Transporters in Health and Disease

Drug active transport

Drug canalicular transporter

Drug disposition transporters

Drug distribution active transport

Drug distribution transport rates

Drug distribution transporters

Drug interactions linked to transporters

Drug interactions transport

Drug metabolism transporters

Drug resistance transporters

Drug transport

Drug transport

Drug transport assay

Drug transport by fluid motion

Drug transport experimental rate constants

Drug transport mechanisms

Drug transport ocular

Drug transport simulation

Drug transporter genes

Drug transporter genes polymorphisms

Drug transporter regulation

Drug transporter-mediated

Drug-transporter-proteins

Drug/metabolite transporters

Drugs metabolism and transport

Endocytosis drug transport

Enzymes, Transporters, and Drugs Highly Sensitive to Induction

Equilibrative drug transport

Ethnicity drug transport

Genetic polymorphisms in drug transporters

Glomerular filtration drug transport

Glomerular filtration rate drug transport

Hepatic drug transporter

Human serum albumin , drug transport

Intestinal drug transport and absorption

Intestinal epithelial cells drug transport across

Intestinal epithelial cells, drug transporters

Iontophoretic drug transport

Kinetics of drug transport

Lamivudine drug transport

Limitations of Caco-2 Cells in Predicting Intestinal Drug Transport

Lipophilic drug absorption lymphatic transport

Lipophilic drugs lymphatic transport

Liver Specific Drug Transport in Sandwich-cultured Hepatocytes

Membrane transporters, as drug targets

Membranes drug transport

Membranes drug transport across

Metabolic and Transport Drug Interaction

Metabolic and Transport Drug Interaction Database

Metabolizing Enzymes and Drug Transporters

Molecular Mechanism of PXR- and CAR-Dependent Drug Transporter Regulation

Molecular drug targets membrane transporters

Monoamine transporters drug targeting

Multi drug transporter

Nasal drug transport studies

Nasal drug transport studies cell culture models

Nasal epithelium drug transport across

Nuclear Receptor-Mediated Regulation of Drug Transporters

Ocular drug delivery transport mechanism

Paracellular drug transport

Passive transport drug absorption

Passive transport drug design

Passive transport, of drugs

Pharmacogenetics drug metabolism and transport

Pharmacogenetics of Drug Transport

Pharmacogenetics of Drug Transporters

Pharmacogenomics of Drug Transport

Pharmacogenomics of Drug Transporters

Pharmacological differences between drug transporters

Physiological Roles of Drug Transporting ABC Proteins - Search for Substrates

Polymorphism drug transporter

Primary cell culture drug transport studies

Primary cultures drug transport studies

Proteins drug-transporting

Proximal tubule drug transport studies

Rate of drug transport

Refractory drug transporter

Regional Differences in Transport and Metabolism of Drugs

Renal drug transporters

Role of Transporters in Drug Absorption

Role of Transporters in Drug Distribution

Role of Transporters in Drug Interactions

Selected drug transporters

Selected drug transporters INDEX

Strategies for Increasing Drug Absorption Targeting Transporters

Systems drug transporter

The ABC Transporters Structural Insights into Drug Transport

The Role of Drug Transporters in RE Development

Tissue drug transport

Transcellular drug transport

Transcellular drug transport carrier-mediated processes

Transcellular drug transport passive diffusion

Transport anticancer drug

Transport drug transporters

Transport drug transporters

Transport mechanisms drug absorption

Transport mechanisms drug action

Transport mechanisms drug distribution

Transport mechanisms drug interactions

Transport of Anticancer Drugs

Transport of drugs

Transport proteins, drug targets

Transport, drug across intestinal wall

Transporter drug discovery process

Transporter drug target

Transporter drugs modulating functions

Transporter properties of drugs

Transporter-mediated drug disposition

Transporter-mediated drug interactions

Transporter-mediated drug interactions clinical implications

Transporters as Targets for Drug Delivery

Transporters drug absorption targeting

Transporters in drug resistance

Transporters, drug SLCO/OATP

Transporters, drug SLCO/OATP family

Transporters, drug action

Transporters, drug interactions

Transporters, drug molecular mechanism

Tubular secretion drug transport

Ultrasound transdermal drug transport

Valacyclovir drug transport

Vectorial drug transport

Vesicles drug transport studies

Zidovudine drug transport

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