Drug resistance transporters

E. Buxbaum. Co-operative binding sites for transported substrates in the multiple drug resistance transporter Mdrl. Eur J Biochem. 265 64—70 (1999). 

The first cloned sequences of the multi-drug resistance transporter (P-glycoprotein, MDR1, ABCB1) were isolated from multi-resistant cell lines in which the gene was strongly amplified. By in-gel renaturation analysis these... 

Nissler, L., Gebhardt, R., and Berger, S., Flavonoid binding to a multi-drug-resistance transporter protein an STD-NMR study. Anal Bioanal Chem., 379, 1045, 2004. 

Katayama K, Masuyama K, Yoshioka S, Hasegawa H, Mitsuhashi J, Sugimoto Y. 2007. Flavonoids inhibit breast cancer resistance protein-mediated drug resistance Transporter specificity and structure-activity relationship. Cancer Chemother Pharmacol 60 789-797. 

Davis, D.R., McAlpine, J.B., Pazoles, C.J., Talbot, M.K, Alder, E.A., White, C., Jonas, B.M., Murray, B.E., Weinstock, G.M., and Rogers, B.L. (2001) Enterococcus faecalis multi-drug resistance transporters application for antibiotic discovery. Journal of Molecular Microbiology and Biotechnology, 3 (2),... 

Ross DD. Modulation of drug resistance transporters as a strategy for treating myelo-dysplastic syndrome. Best Pract Res Clin Haematol 2004 17 641-651. 

Doimenberg, V. S. Meyer, E. M. Donnenberg, A. D. Measurement of multiple drug resistance transporter activity in putative cancer stem/progenitor cells. Methods Mol. Biol. 2009, 568, 261-279. 

Raviv, Y., Pollard, H. B., Bruggemann, E. P., Pastan, I., Gottesman, M. M., Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells, J. Biol. Chem. 1990, 265, 3975-3980. 

Breast Cancer Resistance Protein (BCRP, also known as MXR or ABCP), first cloned from mitoxantrone and anthracycline-resistant breast and colon cancer cells [188, 189] is a half-transporter efflux pump believed to function as a homo-or hetero-dimer. Following its identification, BCRP-mediated drug resistance was observed for topoisomerase inhibitors including camptothecins [190, 191] and in-dolocarbazoles [192]. In normal tissues, BCRP was detected in placental syncytio-trophoblasts, hepatocyte canalicular membrane, apical intestinal epithelia and vascular endothelial cells [193]. These findings support the important role BCRP plays in modulating topotecan bioavailability, fetal exposure and hepatic elimination [194]. Considering that the substrates and tissue distributions for BCRP overlap somewhat with MDR1 and MRPs [195], additional studies will be required to define the relative contribution of each of these transporters in the overall and tis-... 

Allen JD, Brinkhuis RF, van Deemter L, Wijnholds J, Schinkel AH. Extensive contribution of the multidmg transporters P-glycoprotein and Mrpl to basal drug resistance. Cancer Res 2000 60(20) 5761-5766. 

Belinsky, M.G., Chen, Z.S., Shchaveleva, I., Zeng, H. and Kruh, G.D. (2002) Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Research, 62, 6172-6177. 

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