Proximal tubule drug transport studies

Renal transports of urate in the mammalian kidney have a common characteristic feature a secretory and a re absorptive transport oppose each other in the proximal tubule. The proximal tubule (pars convoluta and pars recta) plays the major role in urate transport. The secretory and the reabsorptive transports may be inhibited by the same drugs, the concentrations needed to inhibit one or the other differing in the different species. The secretory transport of urate may involve different carriers in different species. Further studies are needed to determine the role of the peritubular site versus the luminal site of the cells in the reabsorptive and the secretory transports and to characterize the carriers involved. 

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