Pharmacogenetics of Drug Transporters

Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, U.S.A. 

Transporter symbol Chromosome Tissues Polarity Gene bank 

Abbreviations. A, adrenal gland AP, apical B, brain BL, basolateral I, intestine K, kidney L, liver Lu, lung nd, not determined P, placenta T, testis Ub, ubiquitous 

The goal of this review is to summarize the current state of knowledge in the area of pharmacogenetics of human transporters known to be involved in drug disposition. The molecular, biochemical, and physiological role of each transporter will be systematically outlined (Table 1) as well as the functional relevance of genetic polymorphisms in such transporters (Tables 2 and 3, www.vanderbilt.edu/kimlab). 

Rat Oatpl, the first identified member of this family, was cloned from a liver cDNA library (9). In the rat kidney, Oatpl protein is localized to the apical proximal tubules (10), suggesting that this transporter facilitates solute 

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Franke RM, Gardner ER, Sparreboom A (2010) Pharmacogenetics of drug transporters. Curr Pharm Des 16 220-230... 

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