Drug transporter genes

Brinkmann, U., Eichelbaum, M., Polymorphisms in the ABC drug transporter gene MDR1, Pharmacogenomics J. 2001, 3, 59-64. 

Absorption, in general, is treated as a physicochemical transport process based on computations of logP (the octanol/water partition coefficient) and solubility governed by factors such as polar surface area on the molecule. It is conceivable that SNPs in drug transporter genes will affect the pharmacokinetic properties of compounds and, therefore, these may have to be taken into consideration in the design process. 

Staudinger, J.L., Madan, A., Carol, K.M. and Parkinson, A. (2003) Regulation of drug transporter gene expression by nuclear receptors. Drug Metabolism and Disposition, 31, 523-527. 

K., Steiner, I Baumgartner, C. and Muller, M. (2005) Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans. Clinical Pharmacology and Therapeutics, 78, 182-190. 

A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination. Pharmacogenet Genomics, 15, 277—285. 

Siddiqui A et al Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 2002 348 15. 

Hilgendorf, C., Ahlin, G., Seithel, A., Artursson, P., Ungell, A.-L. and Karlsson, J. (2007) Expression of 36 drug transporter genes in human intestine, liver and kidney and in organotypic cell... 

Hayeshi R, Hilgendorf C, Artursson P et al (2008) Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories. Eur J Pharm Sci 18 383-396... 

Nishino, K. and Yamaguchi, A. (2001) Analysis of a complete library of putative drug transporter genes inEscherichia coli. Journal of Bacteriology, 183 (20), 5803-5812. 

D.J., Ward, D.J., Marsden, K., and Bennett, J.E. (1998) Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDHl, in Candida glabrata. Antimicrobial Agents and Chemotherapy, 42, 1695-1701. 

Hulot J S, Villard E, Maguy A, et al. (2005). A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination. Pharmacogenet. Genomics. 15 277-285. 

Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell A-L, and Karlsson J (2007) Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines Drug Metab Dispos 35 1333-1340. 

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