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Drug Transporters in Health and Disease

Drug transporters may show high levels of basal constitutive transcription, or may be activated by external stimuli. The elements and mechanisms involved in constitutive expression (i.e., operative under normal growth conditions) under physiological conditions are described below. [Pg.388]

In summary, solute transporters play an invaluable role in fundamental cellular processes in health and disease, and function as important mediators governing all aspects of drug therapy. Despite the apparent clinical importance of SLC proteins, the knowledge of their structure and mechanism of action has lagged far behind the knowledge of these properties of proteins in general however, this... [Pg.269]

Kalo, R.. Takanaka. A., wd Oshima, T. Effect of vitamin C deficiency on the metabolism of drugs and NAOPH-linked electron transport system in liver microsomes. Jpn. J. Pharmacol.. 19 25-33.1969. Kennedy, J. F. Chemical and biochemical aspecte of the glycosamino-glycans and proteoglycans in health and disease. Adv. Clin. Chem.. 16 1-101.1976. [Pg.608]

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Drug transport

Drug transporters

Drug-disease

Transport and Health

Transport drug transporters

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