Paracellular drug transport

Noach, A. B. J. Enhancement of paracellular drug transport across epithelia—in vitro and in vivo studies, Pharm. World Sci. 17, 58-60 (1995). 

Karlsson, J. Ungell, A.-L. Grasjo, J. Artursson, P., Paracellular drug transport across intestinal epithelia Influence of charge and induced water flux, Eur. J. Pharm. Sci. 9, 47-56 (1999). 

In addition to the aforementioned effects on paracellular drug transport, Ca2+ also plays an important role in the transcytosis of macromolecules. The entry of the plant lectins abrin, modeccin, and viscumin into Vero cells was inhibited in a Ca2+-free medium a well as in a Ca2+-containing medium containing verapamil and Co2+, both inhibitors of Ca2+ [217], Ca2+ is therefore required at a stage after the binding of the above lectins, perhaps in the fusion and exocytosis of membrane vesicles. 

Modulation of CL channels is expected to alter paracellular drug transport across the cornea and the conjunctiva by modulating either net water transport or intracellular levels of Ca2+. In general, epithelia with CL channels secrete CL along... 

UB Kompella, P Ashton, VHL Lee. (1992). Paracellular drug transport in the pigmented rabbit conjunctiva and cornea. Invest Ophthalmol Vis Sci 33 1015. 

Kotze, A.F., Thanou, M.M., LueBen, H.L., De Boer, A.G., Verhoef, J.C., and Junginger, H.E., Enhancement of paracellular drug transport with highly quaternized N-trimethylchitosan chloride in neutral environments In vitro evaluation in intestinal epithelial cells (Caco-2), J. Pharm. Sci., 88 253-257 (1999). 

Hayashi, M., et al. 1999. Physiological mechanism for enhancement of paracellular drug transport. J Control Release 62 141. 

Enhancement of paracellular drug transport with highly quaternized V-trimethyl chitosan chloride in neutral environment in vitro evaluation in intestinal epithelial cells (Caco-2). J. Pharm. Sci. 88 253-257. 

Jumarie Cand Malo C (1991) CACO-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro. J Cell Physiol 149 24-33 Karlsson J, Ungell AL, Artursson P (1994) Effect of an oral rehydration solution on paracellular drug transport in intestinal epithelial cells and tissues assessment of charge and tissue selectivity. Pharm Res 11 248... 

The extent to which the cell line is appropriate for drug metabolism and transport studies. If drug bidirectional transport studies are to be performed, the cell line needs to form monolayers with tight cell-cell junctions. If cell-cell junctions are loose, background (or nontransporter-dependent) paracellular drug transport... 

B. Paracellular drug transport A. Excretion A. Genetic factors... 

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