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Pharmacogenetics of Drug Transport

Individual genetically determined variations in transporter function may contribute to interindividual differences in therapeutic and/or adverse effects of drugs. Several studies have shown that variations in transporter gene sequences do occur. However, the clinical significance of these variations generally is not yet well documented. For example, as discussed in Chapter 4, the intestinal hPEPT-1 transporter plays a role in absorption of peptide-like cephalosporin antibiotics and other drugs. Interindividual variations in hPEPT-1 may account for the large interindividual variations in bioavailability that have been observed (129). [Pg.217]

Nucleotide position Location Effect Allelic frequency Expression mRNA/pro tein Probe drug phenotype [Pg.218]

Franke RM, Gardner ER, Sparreboom A (2010) Pharmacogenetics of drug transporters. Curr Pharm Des 16 220-230... [Pg.112]

See other pages where Pharmacogenetics of Drug Transport is mentioned: [Pg.109]    [Pg.111]    [Pg.113]    [Pg.115]    [Pg.117]    [Pg.119]    [Pg.121]    [Pg.123]    [Pg.125]    [Pg.127]    [Pg.129]    [Pg.131]    [Pg.133]    [Pg.135]    [Pg.137]    [Pg.139]    [Pg.141]    [Pg.143]    [Pg.145]    [Pg.147]    [Pg.149]    [Pg.151]    [Pg.153]    [Pg.156]    [Pg.217]    [Pg.1903]   


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