Membrane transporters, as drug targets

Amidon GL, Sadee W, eds. Membrane transporters as drug targets. New York Kluwer Academic/Plenum Publishers 1999. 

Sadee W, Graul RC, Lee AY. Classification of membrane transporters. In Amidon GL, Sadee W, eds. Membrane transporters as drug targets. New York Kluwer Academic/Plenum Publishers 1999. p. 29-58. 

Rochat, B. Audus, K. L. In Membrane Transporters as Drug Targets Amidon, G., Sadee, W., Eds. Kluwer Academic/Plenum Publishers New York, 1999, pp. 181-200. 

B. Targeting enzymes selective of invading organisms Membrane Transporters as Drug Targets... 

Transporters are the final class of integral membrane proteins that are important as drug targets. Structurally, they are among the most complex receptors known hence, they are ideally suited to analysis via pharmacophore discovery. Catalyst/HypoGen was used in the discovery of a pharmacophore for the Na + /bile acid transporter [61], A... 

Mechanisms of drug action. To mediate a response the drug can bind to the desired therapeutic target or to other molecular targets such as G-protein-coupled receptors (GPCRs), ion channels, or transporters on the cell membrane, or to intracellular targets such as enzymes and nuclear hormone receptors. 

The occurrence of the response to a drug that differs between persons can have many different causes, for instance, variability of drug metabolism as indicated above. Other potential differences may be caused by variation of drug targets or receptors, or of the transporters of drugs that operate at sites of absorption, of the blood brain barrier, or of cellular membranes in general. 

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