Enzymes, Transporters, and Drugs Highly Sensitive to Induction

1 Enzymes, Transporters, and Drugs Highly Sensitive to Induction 

3 CYP2C19. Studies have shown that PXR and CAR regulate hepatic CYP2C19 expression in vitro [21, 22], The metabolism and plasma levels of the CYP2C19 substrates omeprazole [74] and voriconazole [129] are affected by the PXR agonists St. John s wort and rifampin, demonstrating that this enzyme is inducible in vivo. 

2 Therapeutic Implications of Induction-Type Drug Interactions 

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