Transporter drug target

Apart from very few exceptions, the entries in the main text do not contain drug names in their titles. Instead, drugs that are commonly used all over the world are listed in the Appendix. Also included in the Appendix are four-extensive sections that contain tables listing proteins such as receptors, transporters or ion channels, which are of particular interest as drug targets or modulators of drug action. 

There is very little evidence to suggest that soluble or particulate macromolecules can be transported across the buccal mucosa [31]. More work is needed to determine whether this route could be of any benefit in drug targeting. 

Iversen L. Neurotransmitter transporters fruitful targets for CNS drug discovery. Mol Psychiatry 2000 5 357-362. 

Schousboe, A, Sarup, A., Larsson, O. M. and White, H. S. GABA transporters as drug targets for modulation of GABAergic activity. Biochem. Pharmacol. 68 1557-1563. 

Teodori E, Dei S, Martelli C, Scapecchi S, Gualtieri F (2006) The functions and structure of ABC transporters Implications for the design of new inhibitors of P-gp and MRP1 to control multidrug resistance (MDR). Curr Drug Targets 7 893-909. 

Matsukawa Y, Yamahara H, Yamashita F, Lee VH, Crandall ED, Kim KJ (2000) Rates of protein transport across rat alveolar epithelial cell monolayers. J Drug Target 7(5) 335-342... 

Kreuter J, Shamenkov D, Petrov V, Ramge P, Cychutek K, Koch-Brandt C, Alyautdin R (2002) Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier. J Drug Target 10 317-325... 

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