Metabolic and Transport Drug Interaction

These values were obtained from the University of Washington s Metabolism and Transport Drug Interaction Database http //www.druginteractioninfo.org rfOgilvie et al. (217). 

Metabolism and Transport Drug Interaction Database A Web-Based Research and Analysis Tool... 

Figure 2 List of precipitants evaluated with the substrates bupropion and efavirenz and which have shown more than 20% effect in in vivo inhibition. Display from the Metabolism and Transport Drug Interaction Database (http //www.druginteractioninfo...

Metabolism and transport drug interaction database. http //depts. washington.edu/didbase (accessed 2003 Mar 24). 

Although this review focuses specifically on metabolism, the increasing knowledge of the intimate connections between metabolism and transport must be mentioned. There are many situations in which the interaction of transporters with drug metabolites has been explored and has led to the hypothesis that CYP, and other enzymes and transporters, work in concert to keep xenobiotics from crossing the intestinal epithelium.44 17 Cases in which there seems to be coordinate activity to preferentially export drug metabolites have been found in Caco-2 cells and in vivo with esterase enzymes and with CYP enzymes. 

Drug-Drug Interactions with an Emphasis on Drug Metabolism and Transport... 

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