Enzymes drug-metabolizing

Agarwal DK, Seth PK, Gupta PK. 1978. Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat. J Environ Sci Health C13(l) 49-62. 

Sriram K, Misra UK. 1983. Interaction of endosulfan and dietary vitamin A on rat hepatic drug metabolizing enzymes. Acta Vitaminol Enzymol 5 213-218. 

Statistical, Pharmacophore, and Homology Models and Crystal Structures of Drug-Metabolizing Enzymes... 

STATISTICAL, PHARMACOPHORE, AND HOMOLOGY MODELS AND CRYSTAL STRUCTURES OF DRUG-METABOLIZING ENZYMES... 

E (1997) Mechanism of action of dietary chemoprotective agents in rat liver induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism . Carcinogenesis, 18 1729-38. 

MANORAMA R (1993) Hcpatic Drug Metabolizing Enzymes of Rice Bran Oil Fed Rats. Ph D. Thesis submitted to Osmania University, Elyderabad, India. 

Guyan et al. 1990) have used several markers of lipid peroxidation (9-cis-, 11-tmns-isomer of linoleic acid, conjugated dienes and ultraviolet fluorescent products) to demonstrate significant increases in the duodenal aspirate after secretin stimulation in patients with acute and clinic pancreatitis. They interpreted this as indicating induction of hepatic and pancreatic drug-metabolizing enzymes in the face of a shortfidl of antioxidant defences, more marked in chronic pancreatitis. Subsequent studies in patients with chronic pancreatitis have confirmed decreased serum concentrations of selenium, -carotene and vitamin E compared with healthy controls (Uden et al., 1992). Basso aol. (1990) have measured increases in lipid peroxides in the sera of patients with chronic... 

The liver was the first organ in the gastrointestinal tract in which the role of ROMs in liver injury was established. Mitchell et al. (1973a, 1973b) demonstrated the roles of several drug-metabolizing enzymes in the formation of... 

Each plant tissue tends to have an obviously distinctive profile of flavonoids. The flavonoid content can reach about 0.5% in pollen, 10% in propolis, and about 6 mg/kg in honey. Havonoid aglycones appear to be present only in propolis and honey, while pollen contains flavanols in herosidic forms. The flavonoids in honey and propolis have been identified as flavanones and flavanones/flavanols (Campos et ah, 1990). The antimi-crobially active flavanone pinocembrine was foimd to be a major flavonoid in honey (Bogdanov, 1989). Amiot et ah (1989) studied two blossom and two honeydew Swiss honey samples and foimd that pinocembrine was the main flavonoid. Pinocembrine concentration varied between 2 and 3 mg/kg (Bogdanov, 1989). Berahia et ah (1993) analyzed sunflower honey samples and detected six flavone/flavols, four flavanone/ flavols, and pinocembrin, of which pinocembrin is the main flavonoid. The flavonoids in sunflower honey and propolis were characterized and assessed for their effects on hepatic drug-metabolizing enzymes and benzo [fl]pyrene-DNA adduct formation (Sabatier et ah, 1992 Siess et ah, 1996). 

Siess, M. H., Le Bon, A. M., Canivenc-Lavier, M. C., Amiot, M. ]., Sabatier, S., Yaubert, S. Y., and Suschetet, M. (1996). Flavonoids of honey and propolis Characterization and effects on hepatic drug-metabolizing enzymes and benzoja] pyrene-DNA.. Agric. Food Chem. 44, 2297-2301. 

Polymorphic metabolism Genetically determined rates of metabolism (fast vs. slow) by selected isozymes of cytochrome P-450 drug-metabolizing enzymes. 

Meyer, U. A. et al. (1996). Antidepressants and drug-metabolizing enzymes - expert group report. Acta Psychiatr. Scand., 93, 71-9. 

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