MDRl/P-glycoprotein

E. G., Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDRl/P-glycoprotein, Pharm. Res. 2000, 37, 803-810. 

Muller, M., Mayer, R., Hero, U., Keppler, D., ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdrl P-glycoprotein, FEBS Lett. 1994, 343, 168-172. 

A structural model for the open conformation of the mdrl P-glycoprotein based on the MsbA crystal structure. Journal of Biological Chemistry, 278, 30115-30124. 

Van Helvoort, A., Smith, A.J., Sprong, H., Fritzsche, I., Schinke, A.H., Borst, P., Van Meer, G., 1996, MDRl P-glycoprotein is a hpid translocase of broad specificity, while MDRP3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87 507-517. 

G., 1996, MDRl P-glycoprotein is a hpid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87 507-517. 

Rao, V. V., Dahlheimer, J. L., Bardgett, M. E., et al. (1999) Choroid plexus epithelial expression of MDRl P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc. Natl. Acad. Sci. U. S. A. 96, 3900-3905. 

Chaudhary PM, Roninson IB (1992) Activation of MDRl (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncology Research 4 281-290... 

Gruol, D.J., and S. Bourgeois. 1994. Expression of the mdrl P-glycoprotein gene A mechanism of escape from glucocorticoid-induced apoptosis. Biochem Cell Biol 72 561. 

Chen CJ, Chin JE, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986 47(3) 381-389. 

Leith C, Kopecky K, Chen I, Eijdems L, Slovak M, McConnell T, Head D, Weick J, Grever M, Appelbaum F, Wilhnan C. Frequency and clinical significance of the expression of the multidrug resistance proteins MDRl/P-glycoprotein, MRPl, and LRP in acute myeloid leukemia a Southwest Oncology Group Smdy. Blood 1999 94 1086-1099. 

Wojtal KA, De Vries E, Floekstra D, van Ijzendoorn SC. Efficient trafficking of MDRl/P-glycoprotein to apical canalicular plasma 52. membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide. Mol. Biol. Cell 2006 17 3638-3650. 

Marzolini C, Paus E, Buclin T, Kim R. Polymorphisms in human MDRl (P-glycoprotein) Recent advances and clinical relevance. Clin Pharmacol Ther 2004 75 13-33. 

Choi KH, Chen CJ, Kriegler M, Roninson IB. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdrl (P-glycoprotein) gene. Cell 1988 53 519-29. 

Elferink RPJO, Zadina JE (2001) MDRl P-glycoprotein dansports endogenous opioid pepddes. Pepddes 22 2015—2020. 

Evidence for mdrl P-glycoprotein-like transport in fish tissues... 

Oude Elferink, R.P, and Zadina, J. (2001) MDRl P-glycoprotein transports endogenous opioid peptides. Peptides. 22 (12), 2015-2020. 

Kuhnke, D. et al. (2007) MDRl-P-glycoprotein (ABCBl) mediates transport of Alzheimer s amyloid-beta peptides — implications for the mechanisms of Abeta clearance at the blood—brain barrier. Brain Pathology, 17 (4), 347-353. 

Stege A, et al. (2004). Stable and complete overcoming of MDRl/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference. Cancer Gene Ther. ll(ll) 699-706. 

Pichler A, Zelcer N, Prior JL, Kuil AJ, Piwnica-Worms D. In vivo RNA interference-mediated ablation of MDRl P-Glycoprotein. Clin Cancer Res 2005 11 4487-4494. 

Sparreboom A, Planting AS, Jewell RC, van der Burg ME, van der Gaast A, de Bruijn P, Loos WJ, Nooter K, Chandler LH, Paul EM, Wissel PS, Verweij J. Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDRl P-glycoprotein. Anticancer Drugs 1999 10 719-728. 

Sharma V, Prior JL, Belinsky MG, Kruh GD and Piwnica-Worms D. Characterization of a 67 Ga/68 Ga radiopharmaceutical for SPECT and PET of MDRl P-glycoprotein transport activity in vivo validation in multidrug-resistant tumors and at the blood-brain barrier. J Nucl Med 2005 46 354-364. 

Wallstab A, Koester M, Bohme M, and Keppler D (1999) Selective inhibition of MDRl P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918. Br J Cancer 79 1053-1060. 

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