Membranes drug transport across

Freshly isolated or subcultured brain microvascular endothelial cells offer a notable in vitro tool to study drug transport across the blood-brain barrier. Cells can be grown to monolayers on culture plates or permeable membrane supports. The cells retain the major characteristics of brain endothelial cells in vivo, such as the morphology, specific biochemical markers of the blood-brain barrier, and the intercellular tight junctional network. Examples of these markers are y-glutamyl transpeptidase, alkaline phosphatase, von-Willebrandt factor-related antigen, and ZO-1 tight junctional protein. The methods of... 

List the different routes of drug transport across epithelial membranes. 

In the body, drug molecules cross cell membranes, are transported across cells, and many are altered by being metabolised. These movements and changes involve interaction with membranes, carrier proteins and enzymes, either as individual cheiiucal reactions or as processes. The rate at which these movements or changes can take place is subject to important influences that are referred to as the order of reaction or process. In biology generally, two orders of such reactions are recognised, and are summarised as follows ... 

Several mechanisms have been identified for drug transport across membranes. One of them is passive. The remainder utilize some type of carrier mechanism. 

The amount of drug transport across a membrane at steady-state under a sink condition in the receiver can be expressed in terms of the flux (/) and permeability coefficient (P) ... 

Chisty MNA, Bellantone RA, Taft DR, Plakogiannis FM. In vitro evaluation of the release of albuterol sulfate from polymer gels effect of fatty acids on drug transport across biological membranes. Drug Dev Ind Pharm 2002 28(10) 1221—1229. 

Fig. 3.1 Schematic illustration of a targeted drug-delivery principle that involves accumulation of polymer-covered liposomal drug carriers in porous diseased tissue where secretory sPLAj subsequently acts as a local trigger for liposomal drug release and drug transport across the target cell membrane.

Table 1-1-2. The Three Basic Modes of Drug Transport Across a Membrane...

In general, drug transport across any epithelium is dictated by the characteristics of the cell membrane and the physicochemical prop-... 

Drug response, whether therapeutic or toxic, is dictated by drug concentration at sites of action located outside the site of drug administration. Thus, tissue distribution can often be a critical determinant of drug action, and is a complex process that involves drug transport across biological membranes into the blood, and distribution to sites of action or storage and eventually to sites of elimination. 

Drug Transport Across the Hepatic Canalicular Membrane 191... 

List the main transport systems for drug transport across the basolateral and luminal membranes of the proximal tubule cell. 

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