Drug transporter regulation

Most experimental data were derived from rodent models in which drug transporter regulation occurs mostly at the transcriptional level. Posttranscriptional regulation (e.g., targeting and retrieval of transporters from membranes), however, seems to be important in humans also [93, 94]. 

MOLECULAR MECHANISM OF PXR- AND CAR-DEPENDENT DRUG TRANSPORTER REGULATION... 

ME Dowty, P Braquet. (1991). Effect of extracellular pH on cytoplasmic pH and mechanism of pH regulation in cultured bovine corneal endothelium Possible importance in drug transport studies. Int J Pharm 68 231-238. 

Kullak-Ublick, G. A., Regulation of organic anion and drug transporters of the sinusoidal membrane, J. Hepatol. 1999, 31, 563-573. 

Staudinger, J.L., Madan, A., Carol, K.M. and Parkinson, A. (2003) Regulation of drug transporter gene expression by nuclear receptors. Drug Metabolism and Disposition, 31, 523-527. 

K.W. Scotto. Transcriptional regulation of ABC drug transporters. Oncogene. 22 7496-7511 (2003). 

---