Dietary supplements phosphorus

Dietary phosphorus also affects calcium metabolism. Polyphosphate decreases calcium absorption in young men while orthophosphate supplement does not (26J. However, in the rat all forms of phosphate decrease calcium absorption about equally (31). However, widely divergent dietary calcium phosphorus ratios do not seem to affect calcium utilization by people as long as there is adequate phosphorus intake (32). In general phosphorus stimulates calcium retention in man (3277... 

Martini and Wood (2002) tested the bioavailability of 3 different sources of Ca in 12 healthy elderly subjects (9 women and 3 men of mean SEM age 70 3 and 76 6 years, respectively) in a 6-week crossover trial conducted in a Human Study Unit. Each Ca source supplied 1000 mg Ca/day and was ingested for 1 week with meals (as 500 mg Ca 2x/day), thus contributing to a high-Ca intake (1300 mg Ca/day). A low-Ca intake (300 mg Ca/day strictly from the basal diet) was adhered to for 1 week in-between each treatment. The Ca sources included skim milk, CCM-fortified OJ, and a dietary supplement of CaCOa. Assessment parameters were indirect measures predicted to reflect the relative bioavailability of Ca postprandially via an acute PTH suppression test (hourly for 4h). Longer-term responses to Ca supplementation were assessed via a number of urinary and serum hormone, mineral, and bone resorption biomarkers (i.e., vitamin D, Ca, phosphorus, and collagen t) e 1 N-telopeptide cross-links). 

Bone meal is ground up or crushed animal bone. It is put into fertilizer, soil enrichments, and dietary supplements as a source of calcium and phosphorus. 

An ionic compound that is 22.071% manganese, 1.620% hydrogen, 24.887% phosphorus, and 51.422% oxygen is used as a food additive and dietary supplement. What is the empirical formula for this compound What do you think its chemical name is (Consider the possibility that this compound contains more than one polyatomic ion.)... 

White Or grayish -white powder. Odorless, tasteless. Sol in 2300 parts cold water, 1200 parts boiling water more sol in water in presence of H,PO, sol in warm coned solns of alkali citrates. Protect from light. Should not be heated or triturated with chlorates, nitrates, or other oxidizing agents. USE Formerly as dietary supplement for phosphorus. 

Uses Foods (dietary supplement, mineral supplement) pharmaceuticals (tablet diluent excipient abrasive in dentifrices calcium/phosphorus source in multivitamins) stabilizer migrating from food pkg. 

About the middle of the nineteenth century, the use of certain phosphorus compounds (rather than the element) became the vogue. The laxative properties of sodium phosphates were recognised and in the same period hypophosphites (as Na, Mg or Ca salts) were introduced for the treatment of neurasthenia and other nervous deficiencies. These were all considerably less toxic than the element itself and were followed by glycerophosphates (as Na, Ca and other salts) which were believed to function as brain nutrients or nerve tonics . The use of hypophosphites and glycerophosphates persisted well into the twentieth century, but they are now considered to be of very limited value for these purposes. A syrup of phosphorus , described in British Pharmacopea 1885, contained phosphoric acid, sodium phosphate and iron sulphate among other ingredients. Commercial exploitation of products of this kind was inevitable (Hgure 12.22). Modem dietary supplements are often based on collections of vitamins which usually include Bg and B,2. These two vitamins form part of phosphate ester enzymes (e.g. Equation ll.lOSj). 

A wide variety of animal species are subjected to the administration of drugs during their lifetime.The various animal species can encounter drugs and other dietary additives by different routes and this is dependent on the environment in which they are kept. Intensively reared animals tend to have considerable consistency in the components of their diets and thus are much less likely to encounter the range of naturally produced compounds that extensively produced animals encounter. The desire for less expensive dietary constituents and increased efficiency of use has induced feed manufacturers and producers to add enzyme supplements to diets of most farmed animals to reduce the negative effects of indigestible dietary carbohydrates, refactory proteins and unavailable minerals such as phosphorus. This use of dietary additives to improve nutrient utilization and environmental consequences of feeding animals intensively has been the subject of intense research activity in the last five years. " The... 

The rat has been used rather widely to study the relation between dietary protein, or acid salt feeding, and calcium loss. Barzel and Jowsey (19) showed that the rat fed a control diet supplemented with ammonium chloride excreted excessive urinary calcium, and experienced a concomitant loss of fat-free bone tissue. Draper, et al. (20) extending this work, reported an inverse relation between dietary phosphate and loss of bone calcium and dry, fat-free tissue. In subsequent studies (21), they reported that this process was accompanied by reduced serum calcium levels the high phosphorus, low calcium diet increased urinary calcium loss. Whereas, increasing the phosphorus content of the diet stopped the excessive urinary calcium loss. To test possible zinc loss that might result from this sort of acid salt feeding, Jacob and her coworkers (22) fed rats a supplement of ammonium chloride and then measured urinary zinc and calcium. The hypercalciuria occurred exclusive of an effect upon urinary zinc loss. 

High levels of dietary zinc were associated with marked decreases in bone calcium deposition and in the apparent retention of calcium in male weanling albino rats. Marked increases in fecal calcium levels were also observed in the zinc-fed rats. Excessive dietary zinc was associated with a shifting of phosphorus excretion from the urine to the feces. This resulted in an increase in fecal phosphorus and provided an environmental condition which would increase the possibility of the formation of insoluble calcium phosphate salts and a subsequent decrease in calcium bioavailability. The adverse effect of high dietary zinc on calcium status in young rats could be alleviated and/or reversed with calcium supplements. 

Table VIII shows the phosphorus balance of zinc-fed and non-zinc-fed rats supplemented with 0.8% calcium and/or phosphorus. A dietary level of 0.75% zinc was associated with decreases in the apparent retention of phosphorus, and these data support the findings of Sadasivan (2-4). Calcium supplements were associated with slight increases in the retention of phosphorus, while phos-...

The data presented in this paper indicate that excess levels (0.75%) of dietary zinc result in decreases in the bioavailability of calcium and phosphorus in rats and interfere with normal bone mineralization. High dietary levels of calcium or zinc appeared to cause a shift in the excretion of phosphorus from the urine to the feces, while the presence of extra phosphorus tended to keep the pathway of phosphorus excretion via the urine. The presence of large amounts of phosphorus in the Intestinal tract due to high intakes of zinc would increase the possibility of the formation of insoluble phosphate salts with various cations, including calcium, which may be present. A shift in phosphorus excretion from the feces to the urine, however, could result in an environmental condition within the system which would tend to increase the bioavailability of cations to the animal. The adverse effect of zinc toxicity on calcium and phosphorus status of young rats could be alleviated with calcium and/or phosphorus supplements. 

Adhere to a dietary regimen of calcium supplementation and phosphorus restriction avoid excessive use of aluminum-containing compounds... 

The zinc contained in plants is not fully utilized by animals. Diets high in calcium and phosphorus have been associated with poor digestibility of dietary zinc. Diets with large amounts of soy protein are particularly likely to require extra zinc fortification for livestock. Meat is an important source of zinc for human diets. Where supplementation of zinc is indicated, zinc sulfate, zinc oxide, and zinc carbonate are commonly used. 

Table II shows data of the effect of a high phosphorus Intake on the zinc balance. The phosphorus supplements were given to three patients during different calcium Intakes, namely, during a low calcium Intake of 200 mg per day and during higher calcium Intakes of 800 mg and 2000 mg calcium per day. The phosphorus Intake of the subjects studied was approximately 900 mg per day In the control study and was 2000 mg per day during the high phosphorus Intake. In the control study, during a low calcium Intake and a normal phosphorus Intake of 900 mg per day and a dietary zinc Intake of 17 mg per day, the urinary zinc excretion was relatively high, 1.6 mg/day, the fecal zinc excretion was In the expected range and the zinc balance was positive,...

Harrison GE, Howells GR, Pollard J, et al. 1966b. Effect of dietary phosphorus supplementation on the uptake of radioactive strontium in rats. Br J Nutr 21 561-569. 

Low dietary intake of phosphorus has also been associated with poor fertility, with apparent dysfunction of the ovaries causing inhibition, depression or irregularity of oestrus. There are many examples throughout the world of phosphorus supplementation increasing fertility in grazing cattle. In cows, a deficiency of this element may also reduce milk yield. In hens, there is reduced egg yield, hatchability and shell thickness. 

Mineral constituents are essential for normal development of humans. As essential elements are not synthesized in body they must be obtained from dietary sources. They play important roles in the metabolic functions. Calcium and phosphorus are essential for bone structure, potassium and sodium are involved in the functions of all organs, iron, copper and manganese are important for enzymatic functions. Cornelian cherry fruits, being rich in essential elements, might be considered as important nutritional supplements. 

Prevention of rickets and osteomalacia is usually achieved by the provision of adequate dietary calcium (a daily amount equivalent to that in 1 1/2 pints [720 ml] of milk) and making certain that vitamin D is obtained from the diet or from the effect of sunlight on the skin. There is usually sufficient phosphorus present in the diets of people that a deficiency occurs only when there is an abnormally high level of urinary excretion of this element. Therefore, there have been worldwide efforts to promote the fortification of all milk with 400 lU of vitamin D per quart (950 ml). Should this prophylactic measure be unfeeisible in some instancies, calcium and vitamin D might be administered in the form of a mineral and vitamin supplement It is noteworthy that in some areas of the Middle East, infants are fitted with miniature goggles (to proted their eyes) and placed out in the sun in bassinets. 

Vitamin D Vitamin D enhances the efficiency of the small intestine to absorb calcium and phosphorus from the diet and thus helps to maintain normal serum levels of these minerals. Vitamin D deficiency in infants and children results in inadequate mineralization of the skeleton, causing rickets, which is characterized by various bone deformations. The major source of vitamin D is its formation in the skin as a result of exposure to sunlight. Dietary sources include fortified foods, such as milk and cereals, and certain fish. Infant formula is fortified with vitamin D in many countries. Because human milk contains only low amounts of vitamin D, breast-fed infants who do not receive either supplemental vitamin D or adequate exposure to sunlight are at risk for developing vitamin D deficiency. Subclinical vitamin D deficiency can be assessed by measuring serum 25-hydroxyl-vitamin D deficiency occurs months... 

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