High-fat diets

Knockout mice exhibit narcolepsy. hMice under chronic high fat diet. 

DESCHNER E E, RUPERTO J F, WONG G Y and NEWMARK H L (1993) The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet , Nutr Cancer, 20, 199-204. 

HAN L K, ZHENG Y N, XU B J, OKUDA H, KiMURA Y (2002) Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. JNutr. 132 2241-5. 

Diabetes Impaired insulin tolerance in high-fat diet-fed mice Normalizes blood glucose levels [58]... 

Diet Increased risk associated with high-meat and high-fat diets. Decreased intake of 1, 25-dihydroxyvitamin D, vitamin E, lycopene, and /Tcarotene increases risk. 

A number of epidemiologic studies support an association between high fat intake and the risk of prostate cancer. A strong correlation between national per capita fat consumption and national prostate cancer mortality has been reported, and prospective case-control studies suggest that a high-fat diet doubles the risk of prostate cancer. 

Apo E/CXCR3 double knockout mice on a high-fat diet displayed reduced atherosclerotic lesions during early stages of atherogenesis. 

High-fat diet studies with DGATl-/- and DGATl+/- mice demonstrated that the absence of DGAT1 activity may lead to increased insulin sensitivity, leptin sensitivity, protection against diet-induced obesity, and protection against liver steatosis [40-43]. 

In a recent patent application, mice treated with a related iron chelator, deferasirox (DFS), showed reduced body weight while on a high fat diet compared to untreated controls. Additionally, DFS was claimed to improve whole body metabolism and energy expenditure as measured by increased 02 consumption and C02 production as well as a reduction in white adipose and visceral fat, despite little difference between food intake in the control and treated animal groups [25]. 

Another possible explanation for the low R. Q. s obtained after high-fat diets over short periods by Hawley, Johnson and Murlin186 is that in the oxidation of fatty acid chains the uptake of oxygen may outrun the production of carbon dioxide and thus lower the R. Q. Such a process of desaturation would remove the hydrogen but would not produce any carbon dioxide. 

Fatty liver, nonalcoholic fatty liver disease (NAFLD) Rat liver from Male (resistant to NAFLD), Female (sensitive to NAFLD) Fish oil, dextrose Comparison of liver response to high fat diet in male and female suggest pathways contributing to NAFLD [15]... 

These results apparently support those in the previous study however, because dietary fiber was higher in the low fat diet than in the high fat diet, it is impossible to separate the effects of fat, fiber and possibly cholesterol. The alterations used in the low fat, controlled diet were essentially those recommended in the U.S. Dietary Goals/Guidelines while the moderately high fat, self-selected diets resembled usual American dietary intake patterns. 

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