Ciprofloxacin sulfate

The observation that improved remote loading of ciprofloxacin could be achieved using ammonium sulfate solutions rather than sodium citrate buffers highlighted the need for further investigation and development of drug-loading methodologies. In this section, we examine an approach in... 

Interference with T4 absorption Cholestyramine, chromium picolinate, colestipol, ciprofloxacin, proton pump inhibitors, sucralfate, sodium polystyrene sulfonate, raloxifene, sevelamer hydrochloride, aluminum hydroxide, ferrous sulfate, calcium carbonate, bran, soy, coffee. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

An analytical procedure for the determination of ciprofloxacin in serum without previous extraction has been developed by Djurdjevic et al. [11]. The determination was carried out at pH 3, using iron(III) nitrate as the chromogenic agent with the addition of sodium dodecyl sulfate. Absorbance values were measured at 430 nm. The linearity range was between 0.5 and 20pg/mL, with a detection limit of 0.2pg/mL. 

Ciprofloxacin was determined in tablets and intravenous infusion solutions by an oxidative spectrophotometric method [15]. A yellow-orange complex was obtained upon reaction of ciprofloxacin with 5% ammonium sulfamate, 5 N H2S04, and 0.1 M cerium(IV) ammonium sulfate. The complex was extracted into CHC13, dried with anhydrous Na2S04, and measured at 345 nm within up to 4 h. Beer s law was obeyed over the range of 12-120 pg/mL, and the molar absorptivity was found to be 5090. 

Chloramphenicol (Chloromycetin Ophthalmic) Ciprofloxacin (Cipro) Erythromycin Gentamicin sulfate (Garamycin Ophthalmic) Norfloxacin (Chibroxin) Tobramycin (Nebcin, Tobrex) Natamycin (Natacyn Ophthalmic Idoxuridine (IDU) Trifluridine (Viroptic) Vidarabine monohydrate (Vira-A) Dexamethasone Diclofenac Na (Voltaren) Suprofen Profenal) Ketorolac tromethamine (Acular) Olopatadine HCL Ophthalmic solution Medrysone (HMS Liquifilm) Prednisolone acetate Prednisolone Na phosphate Combination TobraDex... 

If ciprofloxacin, a member of the fluoroquinolones family, is prescribed, then it should be given two hours before the patient is given antacids, ferrous sulfate, or sucralfate because these medications lower the absorption of ciprofloxacin. 

Ferrous fumarate, gluconate, sulfate and other iron compounds can reduce the absorption of ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin and sparfloxacin from the gut. Serum levels of the antibacterial may become sub-therapeutic as a result. Limited evidence suggests that fleroxacin is not affected and lomefloxacin is only minimally affected. Glemi-floxacin does not appear to interact when given 2 hours before or 3 hours after ferrous sulfate. No interaction appears to occur with iron-ovotransferrin. Zinc appears to interact like iron. 

The absorption of ciprofloxacin is markedly reduced by iron and zinc compounds. Several studies have clearly demonstrated reductions in the AUC and maximum serum levels of 30 to 90% with ferrous fumarate, ferrous gluconate, ferrous sulfate, iron-glycine sulfate, Centrum Forte (a multi-mineral preparation containing iron, magnesium, zinc, calcium, copper and manganese) and with Stresstabs 600-with-zinc (a multi vitamin-with-zinc preparation). However iron-ovotransferrin has been found to have no significant effect on the absorption of ciprofloxacin. ... 

Polk RE, Healy DP, Sahai J, Drwal L, Racht E. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrcb Agents Chemo er (1989) 33, 1841. ... 

Wong PY, Zhu M, Li RC. Pharmacokinetic and pharmacodynamic interactions between intravenous ciprofloxacin and oral ferrous sulfate. J Chemother (2000) 12, 286-93. 

Seven paralytic shellfish toxins (PSTs), namely decarbamoylsaxitoxin (dcSTX), saxitoxin (STX), neosaxitoxin (NEO), gonyautoxin-2 (GTX-2), gonyautoxin-3 (GIX-3), gonyautoxin-1 (GTX-1), and gonyautoxin-4 (GTX-4) Antibiotics residues (amoxicillin, doxycycline hydrochloride, streptomycin sulfate, thiamphenicol, florphenicol, nifursol, enrofloxacin, ciprofloxacin, norfloxacin) from poultry and porcine tissues Quinolones [enrofloxacin (ENR), ciprofloxacin (CPR), danofloxacin (DAN), difloxacin (DIF), marbofloxacin (MAR), flumequine (FLU), and oxolinic acid (OXA)] in pig kidney tissue... 

The determination of amoxicilline, ciprofloxacin, and piroxicam in bulk and pharmaceutical preparations has been performed by combining the oxidation character of Fe(III) with the chelation property of Fe(II), affording highly colored complexes. The reagent solutions are (1) a mixture of 1,10-phenanthroline and iron(III) ammonium sulfate in hydrochloride medium and (2) 2,2 -bipyridyl and iron(III) ammonium sulfate in hydrochloride medium. The resulting Fe(II) concentration, proportional to the amount of drug present, is monitored by the measurement of absorbances of tris(o-phenanthro-line) iron(U) or tris (bipyridyl) iron(II) complexes at 510 and 522 nm, respectively. 

Turel I, Leban I, Zupandc M, Bukovec P, Gruber K (1996) An adduct of magnesium sulfate with a member of the quinolone family (Ciprofloxacin). Acta CrystaUogr Sect C 52 2443—2445... 

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