Sevelamer hydrochloride

Interference with T4 absorption Cholestyramine, chromium picolinate, colestipol, ciprofloxacin, proton pump inhibitors, sucralfate, sodium polystyrene sulfonate, raloxifene, sevelamer hydrochloride, aluminum hydroxide, ferrous sulfate, calcium carbonate, bran, soy, coffee. 

Common Name Sevelamer hydrochloride Structural Formula ... 

Burke S, Amin N, Incerti C, Plone M, Watson N. Sevelamer hydrochloride (Renagel), a nonabsorbed phosphate-binding polymer, does not interfere with digoxin or warfarin pharmacokinetics. J Clin Pharmacol 2001 41(2) 193-8. 

Chertow GM, et al. Long-term effects of sevelamer hydrochloride on the calcium x phosphate product and lipid profile of haemodialysis patients. Nephrol Dial Transplant 2000 15 559. 

Burke SK, et al. Sevelamer hydrochloride (Renagel), a phosphatebinding polymer, does not alter the pharmacokinetics of two commonly used antihypertensives in healthy volunteers. J CUn Pharmacol 2001 41 199-205. 

Bleyer AJ, et al. A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients. Am J Kidney Dis 1999 33 694-701. 

Sevelamer hydrochloride is a phosphate binder, which decreases intestinal phosphate absorption by binding to phosphate in the GI tract. It is indicated in the reduction of serum phosphorus in patients with chronic kidney disease who are on hemodialysis. 

The concurrent use of a single 2.418-g dose of sevelamer hydrochloride (equivalent to 6 capsules) and did not alter the AUC of a single 20-mg dose of enalapril or its active metabolite, enalaprilat, in 28 healthy subjects. Thus it appears that sevelamer does not bind to enalapril within the gut to reduce its absorption. 

Kays MB, Overiiolser BR, Mueller BA, Moe SM, SowinddKM. Effectsof sevelamer hydrochloride and calcium acetate cn the oral bioavailability of cqrrofloxaciiL Am J Kidney Dis (2003) 42,1253-9. 

Renagel Capsules (Sevelamer hydrochloride). Genome. US Prescribii information, April... 

Add-base balance Sevelamer hydrochloride can cause a metabolic acidosis, which is of particular concern in children, as it can contribute to poor growth [60 ]. 

Fan S, Ross C, Mitra S, Kalra P, Heaton J, Hunter J, Plone M, Pritchard N. A randomized crossover design study of sevelamer carbonate powder and sevelamer hydrochloride tablets in chronic kidney disease patients on haemodialysis. Nephrol Dial Transplant 2009 24(12) 3794-9. 

Although agents that contain aluminium are highly efficient as phosphate binders, they are no longer widely used because of proven neurotoxicity and osteotoxicity. They are gradually being replaced by safer calcium-based salts, or calcium-free compounds, such as sevelamer hydrochloride and lanthanum carbonate [1 ]. 

Add-base balance Sevelamer hydrochloride is an ion-exchange resin, used to reduce serum phosphorus concentrations in patients with chronic kidney disease, that can cause a... 

After successful multiphase chnical trials as the first metal-free phosphate sequestrant for the treatment of hyperphosphatemia, polymer Scheme 6 was approved in the United States by the FDA in 1998 under the generic name of sevelamer hydrochloride. It has been marketed since under the brand name Renagel by Genzyme Corporation. 

---