Chemical structure and carcinogenicity

R. Preussmann, H. Druckrey, S. Ivankovic, and A. von Hodenberg, Chemical structure and carcinogenicity of aliphatic hydrazo, azo, and azoxy compounds and of triazenes, potential in vivo alkylating agents, Ann. N. Y. Acad. Sci. 163, 697-714 (1969). 

Since the spectrum of dibenz [ ,]i]anthracene was not identical to that of the carcinogenic tars, carcinogenic activity obviously was not confined to a unique chemical structure and indeed Cook, who had joined this research effort in 1929, soon synthesized a number of new hydrocarbons, and many of these were carcinogenic. 

Toxicologists have begun to understand how the chemical structure and some of the other properties of these chemicals contribute to their carcinogenicity. One important part of the effort to reduce reliance upon animal testing involves further validation of the use of chemical structure information along with other properties of a chemical - its... 

Because of their diversity of chemical structures and differing physical properties, mycotoxins exhibit a wide array of biological effects on mammalian systems and individual mycotoxins can be genotoxic, mutagenic, carcinogenic, embryotoxic, teratogenic or oestrogenic (Smith and Henderson, 1991). Some... 

R. Benigni, Structure-activity relationship studies of chemical mutagens and carcinogens Mechanistic investigations and prediction approaches. Chem. Rev. 105, 1767-1800 (2005)... 

Hansch, C., Structure-activity relationships of chemical mutagens and carcinogens, Sci. Total Environ., 109/110, 17-29, 1991. 

Woo, Y. T., and Lai, D. (2003). Mechanisms of action of chemical carcint ens and their role in structure-activity relationships (SAR) analysis and risk assessment. In Quantitative Structure-Activity Relationship (QSAR) Models of Chemical Mutagens and Carcinogens, Benigni, R., ed., CRC Press, Boca Raton, FL, pp. 41-80. 

The carcinogens can be subdivided into different groups on the basis of their chemical structure, and for most carcinogens specific target organs are knovm (see Table 2.4). 

Ashby, J., and D. Paton (1993). The Influence of Chemical Structure on the Extent and Sites of Carcinogenesis for 522 Rodent Carcinogens and 55 Different Human Carcinogen Estytosurts."Mutation Research 286, 3-74. 

There are numerous methods available to identify the potential for chemicals to cause both healtli conditions and adverse effects on tlie eiiviroiiment. These can include, but are not limited to, toxicology, epidemiology, molecular and atomic structural analysis, MSDS sheets, engineering approaches to problem solving, fate of chemicals, and carcinogenic versus non-carcinogenic healtli hazards... 

Ashby J, Tennant RW. 1990. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat Res 257 229-306. 

Loew CH, Rebagliati M, Poulsen M. 1984. Metabolism and relative carcinogenic potency of chloroethanes a quantum chemical structure-activity study. Cancer Biochem Biophys 7 109-132. 

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