Damages carcinogen chemical

DNA-damaging carcinogens. These are genotoxic/mutagenic agents, which react chemically with DNA to cause mutations. 

Dr. Ames also indicates that almost every plant product in the supermarket is likely to contain natural carcinogens. He estimates the typical American eats about ten thousand times more natural pesticides than the residue of man-made agricultural pesticides ingested. Thus about 99.99 percent of the pesticides we take in each day are natural and only 0.01 percent are man-made. (The referenced article provides a detailed discussion focusing on the fact the human body is a marvelous machine, designed to survive and prosper in a hostile world. A major section of the article describes the work of the enzymes that successfully deal with carcinogen chemical damage to our DNA.)... 

A number of external factors can lead to DNA damage and thus to mutations. These include especially the effects of carcinogenic chemicals and UV, X-ray, and other high-energy radiation (e. g., radioactivity). 

In this connection, crystal structures of the (+) - trans-anti-1 i a P D E- N2-dG adduct in the Y-family lesion bypass DNA polymerase IV (Dpo4) (see also Chapter 15 by Chandani and Loechler) from the archaeon Sulfolobus solfataricus reveal that the favored P domain is preserved in the enzyme in this case [51], Overall, a survey of crystal structures of DNA damaged by polycyclic carcinogenic chemicals shows that structures observed in DNA duplexes in solution by high-resolution NMR methods are often observed in polymerases [37] however, the preferred P domain can be overridden by strong lesion-polymerase interactions, as was manifested in a crystal structure of a B[a]PDE-derived adenine lesion [52],... 

Toxicology LD50 (IP, rat) 403 mg/kg, (subcut., mouse) 830 mg/kg mod. toxic by ing., IP, subcut. routes CNS depressant inh. can probably cause si. nose/throat irritation, mild CNS depression high doses can cause unconsciousness, death probable skin and si. eye irritant may be si. absorbed thru skin liq. may cause temporary corneal damage related chemicals are suspected human carcinogens mutagen TSCA iisted... 

Kesavan, P. C., 1992, Protection by caffeine against oxic radiation damage and chemical carcinogens Mechanistic considerations, Curr. Sci. 62 791-797. 

See Section 5.8.2 for a description of the Ames lest. Approximately 85% of carcinogenic chemicals are detected by the Ames test, i.e., the correlation between the Ames test for mutagenicity, on the one hand, and carcinogenicity tests in animals, on the other, is about 85%. The Ames test produces both false positives and false negatives. It is not able to predict chromosomal damage because it is performed in prokaryotes, which lack chromosomes. 

Some occupational hygiene aspects of man-made mineral fibres and new technology fibres Safe handling requirements dunng explosive, propellant and pyrotechnic manufacture Simplified calculations of blast induced injuries and damage Laboratory work with chemical carcinogens and oncogenes Rosin (colophony) a review... 

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