Targeting and relevancy

Use cell and tissue culture models that possess appropriate OP compound targets and relevant OP compound-metabolizing systems. 

Identify known or predicted risks based on the nature of the target, the intended MOA of the target, and relevance of animal species to predict such risks associated with a given biopharmaceutical (discussed in Section 3.2). 

The resource limits the isotope chemist must deal with include the timeline, budget, laboratory facilities and equipment, regulatory requirements, the availability of labeled and unlabeled chemical intermediates and standards, unlabeled target and relevant synthetic experimental procedures. 

Significant work continues by both the academic groups and the pharmaceutical industry to validate the FASH targets and discover relevant inhibitors. A selection of some efforts to inhibit bacterial fatty acid biosynthesis at various stages is presented in this chapter. 

Melatonin receptor agonists and their relevance for the treatment of sleep disorders and major depression have been previously reviewed in Ann. Rep. Med. Chem., volume 39 [29]. Since then, ramelteon has been approved, representing an important milestone for the proof of concept of this target, and has opened new possibilities for research. 

The group recognizes that a major practical problem is lack of information of biotransformation and relevant receptor or target site of many chemicals. In such cases, the chemicals should be classified using computer-based structure-toxicity relationships and expert judgment and experience. 

---