Detoxification chemical carcinogens, effect

OrganosuUur compounds have been shown to modulate the activity of glutathione -transferases (GST), a family of enzymes important in detoxification of carcinogens [24], and cytochromes P450 (CYP), a family of enzymes that activate many chemical carcinogens in experimental animals [25]. The effect of proteases inhibition is a new aspect of the biological activity of these plants and further research should be carried out to identify the specific compounds from Allium or Allium products that are responsible for this biochemical effect. 

It is not known how chemicals cause cancer. A fascinating aspect of the story is that many "carcinogenic" chemicals are in fact, not the culprits responsible for cancer induction. The metabolic processes of the body change the chemicals from relatively innocuous substances into reactive intermediates which in as yet unknown fashion, trigger the chain of events which finally result in tumor formation. In other words, chemical carcinogenesis is an effect of "failed" detoxification. 

DES (diethylstilbestrol), xiii, 106, 115, 206 detoxification, 34 developmental toxicity, 103 dibenz(a,h)anthracene, 112 diet, 5, 13-14,106 as exposure pathway, 13-14 chemical composition of, 5 effect on absorption of chemicals, 29 natural carcinogens in, 229-31 role in cancer, 116—20, 154-6 role in cancer prevention, 230 Dioscorides, 39 dioxin, xiii, 54, 164, 180 distribution of chemicals in body, 31-2 DNA damage, 150-3, 156 Doll, R. (Sir), 117-20, 155, 177 Donora, Pennsylvania, 81 dose, 16,39,48,71 absorbed, 27-31, 161 acute, 160... 

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