Chemical carcinogenesis/carcinogens

A2 - Suspected human carcinogens. Chemical substances, or substances associated with industrial process, which are suspect of inducing cancer, based on their limited epidemiological evidence or demonstration of carcinogenesis in one or more animal species by appropriate methods. 

Third, reactions of activated species of chemical carcinogens with DNA are thought to be of great importance in chemical carcinogenesis. Some chemicals (eg, benzojajpyrene) require activation by monooxygenases... 

It is not known how chemicals cause cancer. A fascinating aspect of the story is that many "carcinogenic" chemicals are in fact, not the culprits responsible for cancer induction. The metabolic processes of the body change the chemicals from relatively innocuous substances into reactive intermediates which in as yet unknown fashion, trigger the chain of events which finally result in tumor formation. In other words, chemical carcinogenesis is an effect of "failed" detoxification. 

Ihansplacental Carcinogenesis Certain chemical carcinogens, given to pregnant animals, are potent... 

The use of mutagenic test systems to identify possible chemical carcinogens is based on three major developments in the fields of chemical carcinogenesis and chemical mutagenesis (1) the recognition that chem-... 

MILLER, E.C. and MILLER, J.A. (1976) The metabolism of chemical carcinogens to reactive electrophiles and their possible mechanism of action in carcinogenesis. In Chemical Carcinogens, edited by C.E.Searle (Washington D.C. American Chemical Society). 

Slaga, T.J. and J. DiGiovanni Inhibition of chemical carcinogenesis in Chemical carcinogens. Second edition, edited by C.E. Searle, American Chemical Society Monograph 182, American Chemical Society, Washington, DC (1984) pp. 1279-1321. 

Miller, E.C., and Miller, J.A., "The Metabolism of Chemical Carcinogens to Reactive Electrophiles and Their Possible Mechanisms of Action In Carcinogenesis", In "Chemical Care 1 nogens", ACS Monograph 173, Searle, C.,... 

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