Carcinogenic chemicals, list

The chemical should not contain any chemicals that are a carcinogen or that are known to cause reproductive toxicity. Carcinogens are defined as those chemicals listed in the current edition of the Annual Report on Carcinogens, U.S. Department of Health and Human Services, National Toxicology Program. Chemicals known to cause reproductive toxicity, for example, are defined as those hsted by the state of California under the Safe Drinking Water and Toxic Enforcement Act of 1986 (Cah-fomia Code of Regulations, Title 22, Division 2, Subdivision 1, Chapter 3, Sections 1200, et seq.)... 

Notes All chemicals listed target the skin and eyes. Entries with C after their names are known or suspected carcinogens. Those with T after their names are teratogenic. Abbreviations RES, respiratory system CNS, central nervous system PNS, peripheral nervous system GI, gastrointestinal system KID, kidneys LIV, liver RPS, reproductive system. 

For TSCA Inventory purposes, the EPA distinguishes silica gel (CASRN 63231-67-4), and silica fumes, (CASRN 69012-64-2), as unique chemical substances. The EPA takes the position that manufacturers are free to describe these types of substances in promotional literature and in Material Safety Data Sheets (MSDS) in any way they wish. For example, the substance silica, crystalline, has no CASRN assigned to it and does not appear on the TSCA Inventory, but it has been listed by California under Proposition 65 as a carcinogen. The list of various forms of silica in Table 4.1 does not contain forms that are specifically described as being crystalline, but two of them (CASRN 112945-52-5 and 112926-00-8) clearly state that they are not crystalline (crystalline-free). Some suppliers may use these CAS numbers on their MSDS to assure California customers that their products are not subject to a Proposition-65 warning, even though the correct CASRN for TSCA purposes is 76310-86-9. 

As can be seen, the list contains some of the most toxic and carcinogenic chemical agents with high relevance to workplaces or industrial processes. 

Table 3.5 lists important general classes of chemicals for which some members (but not necessarily all) have been identified as being carcinogenic substances. Listed for each general class are representative compounds that are "reasonably anticipated to be carcinogens" based on animal tests, selected from lists of substances identified as... 

The food additive and GRAS rules apphcable to human foods generally apply to animal food ingredients. However, the Delaney clause s prohibition against carcinogenic substances in food additives was amended to permit carcinogenic chemicals to be fed to animals if the animals are not adversely affected and no residue can be found after slaughter. A list of food additives approved for use in animal food is described in Ref. 20. 

Class II Type A models recirculate 70 percent of the air flowing through the cabinet, and 30 percent is exhausted into the room. Because a majority of the air in the cabinet is recirculated, the Qass II Type A cabinet must not be used with explosive, flammable, or toxic substances, including radioactive or carcinogenic chemicals. Table 9.1 lists some of the performance characteristics of the four types of Class II cabinets. 

Compiled from multiple sources, including (11, 277, 311, 317, 321, 400, 508). Chemicals listed are representative of those found in a typical biochemistry laboratory. In addition, OSHA carcinogens and representative chemicals of other hazard classifications are included for illustrative purposes. CAUTION The absence of any chemical from this table does NOT imply that that chemical is without hazard the choice of these particular chemicals from among the thousands of known hazardous chemicals does not imply that these chemicals are any more or less hazardous than any others. See Chapter 12 for more information. 

FDA/EPA PESTICIDES REF. STANDARDS 200 U.S. INTERNATIONAL TRADE COMMISSION NBS XRAY CRYSTAL 50-29-3.01 NSF CHEMICALS LIST 138 PHS-149 CARCINOGENS A0240 NIOSH RTECS KJ33250... 

De Minimis Limitation. A listed toxic chemical does not have to be considered if it Is present in a mixture at a concentration below a specified de nvnimis level. The de minimis level is 1.0%, or 0.1% if the chemical meets the OSHA carcinogen standard. See Table II for the de minimis value associated with each listed toxic chemical. For mixtures that contain more than one member of a listed chemical category, the de minimis level applies to the aggregate concentration of all such members and not to each individually. EPA included the de minimis exemption In the njle as a burden reducing step, primarily because facilities are not likely to have information on the presence of a chemical in a mixture or trade name product beyond that available in the product s MSDS. The de minimis levels are consistent with OSHA requirements lor development of MSDS information concerning composition. 

For listed chemicals with the qualifier "solution, such as ammonium nitrate, at concentrations of 1 percent (or 0.1 percent in the case of a carcinogen) or greater, the chemical concentrations must be factored into threshold and release calculations because threshold and release amounts relate to the amount of chemical in solution not the amount of solution. 

Liver cancer can also be a consequence of exposure to hepatotoxic chemicals. Natural hepatocarcinogens include fungal aflatoxins. Synthetic hepato-carcinogens include nitrosoamines, certain chlorinated hydrocarbons, polychlorinated biphenyls (PCBs), chloroform, carbon tetrachloride, dimethyl-benzanthracene, and vinyl chloride.Table 5.15 lists the chemical compounds that induce liver cancer or cirrhosis in experimental animals or... 

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